Nitric Oxide Endothelial Function
Better Circulation and Blood Flow
Stronger, More Flexible Vessels
Reduced Swelling and Inflammation
Smooth Blood Platelets
Stronger, More Flexible Blood Cell Membranes
Anti-lipid Oxidation
Better Circulation and Blood Flow Improve Nitric Oxide Endothelial Function Stronger, More Flexible Vessels Reduced Inflammation and Swelling Smooth Blood Platelets Stronger, More Flexible Blood Cell Membranes Reduce Lipid Oxidation

Improve Blood Flow and Cardio-Protective Antioxidant Levels with Flavay®

Flavay: 65 years of science

Sold world-wide for vascular benefits and extensively tested in humans over a period of 65 years, the cardio-protective activity of Flavay® has been established by many significant studies, demonstrating many important ways in which Flavay® improves blood flow—and improve quality of life.

Nitric Oxide Endothelial Function

Flavay® Improves Nitric Oxide Levels by Improving Endothelial Function

Flavay® Stimulates Endothelial Nitric Oxide

Both in vivo and clinical studies demonstrate that taking Flavay® favorably stimulates production of endothelial nitric oxide (eNOS). (261,343,344,361,362,419,421,436,437,438)

Flavay® is shown to improve vasodilation and mildly inhibit angiotensin-converting enzyme (ACE) by modulating nitric oxide metabolism in endothelial cells. (292,296,358)

Flavay improves endothelial function and nitric oxide levels in endothelial cells and platelets. Blood flow increases, muscles surrounding vessels relax, platelets relax (unsticky)

Flavay® improves endothelial function which improves endothelial nitric oxide so blood flow increases, muscles surrounding vessels relax and platelets relax (unsticky). (239,265,286,287,292,296)

Flavay® Also Protects Against
Nitric Oxide Toxicity

Too much nitric oxide can be deadly.

Nitric oxide is essential for normal blood circulation as it controls the muscular tone of blood vessels and regulates circulation and blood flow. However, excessive amounts of nitric oxide can be deadly to the cardiovascular system and actually contribute to heart disease and strokes, and many other apparently different disorders (such as arthritis, asthma and Alzheimer's disease). (10,239,265,292,296)

Flavay® Improves Endothelial Dysfunction

Flavay® is shown to balance nitric oxide activity, both to stimulate normal synthesis and inhibit over-production of nitric oxide. Studies show Flavay® protects against toxic overproduction of nitric oxide by blocking nitric oxide synthases (NOSs). (10,53,261,265,302,306,315,372,414)

So, for good cardiovascular health, the body needs the right balance of nitric oxide—and that's what Flavay® effectively does. (10,239,265,292,296)

Better Circulation and Blood Flow

Flavay® Improves Circulation, Capillary Resistance, and Decreases Capillary Permeability

Flavay® Improves Blood Flow

Flavay - International and U.S. Patents and Clinically Proven

Clinically Proven Since 1947

For more than 65 years, Flavay® is clinically proven to improve circulation, lessen impaired venous backflow, seal leaky capillaries and prevent outflow of blood or liquid. (44-48,249,250)

Flavay® is shown to increase capillary resistance, decrease capillary permeability, and increase rate of lymph flow. (47,48,82,205)

Flavay clinical trial of persons with serious venous problems shows 96% experienced improvement in circulation. 41% very good improvement, 28% good improvement, 27% improvement.

75 out of 78 (96%) subjects with serious circulation problems found very good improvement in taking Flavay®. (44)

Stronger, More Flexible Vessels

Flavay® Strengthens Collagen and Elastin in Vessel Walls

Flavay® Activates Collagen Production and Inhibits Degradation

Stronger, Flexible Vessels Keep Blood Flowing

Flavay® strengthens collagen in vascular walls and capillaries by making the vessels stronger and more elastic. Flavay® is shown to strengthen and rebuild the body’s natural collagen proteins and has the remarkable ability to reactivate collagen and elastin. Flavay® is also a strong antioxidant which protects collagen, elastin and hyaluronic acid from over-crosslinking and destructive inflammation-produced enzymes. (18,25,61,74,81)

Weak veins are enlarged, bulging and twisted with warped weak valves, thin vein walls, irregular blood flow, and result in edema, swollen legs, ankles and feet. Healthy veins provide good circulation to heart, regular blood flow with normal vein walls and valves.

(Above:) For more than 65 years, Flavay® is clinically proven to improve circulation, lessen impaired venous backflow, seal leaky capillaries and prevent outflow of blood or liquid. (44-48,249,250)

Reduced Swelling and Inflammation

Flavay® Inhibits Release and Synthesis of Pro-Inflammatory Compounds

We now know that cardiovascular disease is associated to an inflammatory process. Atherosclerosis is characterized by chronic low grade inflammation of arteries which results in an accumulation of lipids and macrophages/lymphocytes—a systemic inflammatory process. (391,438)

Flavay® Decreases Pro-Inflammatory Molecules

Flavay® Inhibits Destructive Arachidonic Acid Pathway

Oxidative stress produces an increase in enzymes such as cyclooxygenase (COX) and lipoxygenase (LOX) which are implicated in the release of interleukins and chemokines, and it has been shown that Flavay® inhibits these pro-inflammatory enzymes. (391,185,230,387,388)

Important anti-inflammatory mechanisms of Flavay® are the inhibition of pro-inflammatory mediators including phospholipase A2, cyclooxygenase (COX-1 and COX-2), and lipoxygenase thereby reducing destructive ratios and concentrations of prostanoids, leukotrienes and thromboxanes. (Most importantly, this protection comes without the side effects common to NSAIDs.) (53,185,230,265,274,292,296,302)

Inhibit the Destructive Cascade of Arachidonic Acid with Flavay. Chart oxidative stress activates phospholipase A-2, PLA2, which activates arachidonic acid in phospholipids in cell membranes. Cascades down two pathways, lipoxygenases (LOX) and cyclooxygenases (COX-1 and COX-2). Protecting against destructive ratios and concentrations of thromboxanes, prostaglandins, leukotrines, 12-Hydroxyeicosatetraenoic acid (12-HETE) and 15-Hydroxyeicosatetraenoic acid (15-HETE). Imbalances of 12-Hydroxyeicosatetraenoic acid (12-HETE) and 15-Hydroxyeicosatetraenoic acid (15-HETE) lead to inflammation, asthma, Alzheimer's, metabolic syndrome. Imbalances of prostaglandins and leukotrines lead to inflammation, atherosclerosis, joint destruction. Imbalances in thromboxanes leads to abnormal platelet aggregation, vasoconstriction.

An important anti-inflammatory mechanism of Flavay® is the inhibition of pro-inflammatory mediators including phospholipase A2, cyclooxygenase (COX-1 and COX-2), and lipoxygenase thereby reducing destructive ratios and concentrations of prostanoids, leukotrienes and thromboxanes. (53,185,230,265,274,292,296,302)

C-Reactive Protein (CRP) and Myeloperoxidase (MPO)

Taking Flavay is shown to decrease levels of proinflammatory molecules C-reactive protein (CRP), interleukin-6 and tumor necrosis factoralpha (TNF-alpha). (435)

Flavay® is shown to significantly suppress gastric mucosal injury, in a dose-dependent manner, in vivo. Myeloperoxidase (MPO) activities (marker of inflammation) are also significantly inhibited. Endogenous antioxidant, superoxide dismutase (SOD) activities are significantly stimulated by Flavay®. As to gastrointestinal hormones, the secretion of gastrin, somatostatin, and histamine are significantly inhibited, while prostaglandin E2 secretion are significantly stimulated. (425)

Adhesion Molecules/Inflammation

Research also shows Flavay® is beneficial for cardiovascular health as it modulates monocyte adhesion during the inflammatory process. Flavay® is found to decrease the expression of cell adhesion molecules on endothelial cells. (396,434,440,441,442)

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Flavay® Reduces Inflammation in Clinical Trials

Flavay® has been sold worldwide for reducing inflammation and edema (swelling) and extensively tested in humans for more than 65 years.

69% of those taking Flavay reported
            50% reduction in clinical parameter scores for pain, paresthesias (burning, numbness, tingling, or prickling), nocturnal cramps and edema (swelling).

A double-blind, placebo-controlled study of 92 persons with chronic inflammation caused by chronic venous insufficiency (CVI) demonstrated improved venous function at a daily dose of 300 mg Flavay® for 28 days. 69% of those taking Flavay® reported 50% reduction in clinical parameter scores for pain, paresthesias (burning, numbness, tingling, or prickling), nocturnal cramps and swelling (edema). (48)

Flavay® reduces inflammation by preventing release of compounds that promote inflammation, including histamine, serine proteases, prostaglandins and leukotrienes. (18,25,61,74,81)

Smooth Blood Platelets

Flavay® Normalizes Reactivity
(“Stickiness”) of Blood Platelets

Flavay® Normalizes Reactivity
(“Stickiness”) of Blood Platelets

Flavay® reduces platelet aggregation (“sticky blood”) as it aids in production of endothelial nitric oxide which helps to dilate blood vessels and causes blood platelets return to their normal smooth condition. (10,38-54,103,202,286,287)

Stronger, More Flexible Blood Cell Membranes

Stronger, More Flexible Red Blood Cell Membranes

Flavay® Strengthens the Membrane Protein Structure of Blood Cells

Flavay® Favorably Increases Erythrocyte Deformability

As Flavay® strengthens connective tissue in vessel walls, studies show Flavay® improves the membrane protein structure of red blood cells so they can flex and change shape during circulation. Red blood cells must change shape extensively without rupturing for micro-circulation. Human clinical trials of persons with diabetes show Flavay® increases erythrocyte (red blood cell) deformability (flexibility) without increasing viscosity (resistance). (70,182,183)

Anti-lipid Oxidation

Flavay® Decreases Levels of Cardiac Oxidative Stressors

Flavay® Decreases Levels of Oxidative Stressors

thereby Reducing Oxidation of Low Density Lipoproteins (LDL)

In vivo and clinical experiments show that Flavay® decreases cardiac levels of reactive oxygen species (ROS) and malondialdehyde (MDA), a metabolite which forms when ROS and oxidized low density lipoproteins (LDL) attack fatty acids in cell membranes. (438)

Clinical studies shows taking Flavay® increases antioxidant capacity of plasma, decreases oxidation of low density lipoproteins (LDL) and favorably effects lipid profile. (144,145,277,283,284)

Antioxidant and Anti-inflammatory Actions of Flavay. Recycles and improves activities of vitamin C, and protective effects of vitamin E and activity of vitamin A. Protects against lipid peroxidation damage. Highly reactive in both lipid (fat) and aqueous (water) phases of oxidation. Helps balance nitric oxide activity, both to stimulate normal synthesis and inhibit over-production of nitric oxide. Improves total antioxidant capacity and stimulates antioxidant defense systems. Superior antioxidant activity and DNA protection in studies comparing against vitamins C, E and beta carotene (vitamin A).

Patented Antioxidant and
Anti-inflammatory Actions of Flavay®

  • Regenerates and improves intracellular activity of vitamin C and protective effects of vitamin E and activity of vitamin A. (83,33,274,276,63,64,71)
  • Taking Flavay® increases increases vitamin E (a-tocopherol) antioxidant levels in endothelial cells. (292)
  • Clinical studies shows taking Flavay® increases antioxidant capacity of plasma, decreases oxidation of LDL cholesterol and favorably effects lipid profile. (144,145,277,283,284)
  • Clinical studies demonstrate the antioxidant mechanism of Flavay as evidenced by decreased lipid peroxidation of LDL cholesterol. (272)
  • Protects against lipid peroxidation damage. Highly reactive in both lipid (fat) and aqueous (water) phases of oxidation. (277,283,284,299)
  • Helps balance nitric oxide activity, both to stimulate normal synthesis and inhibit over-production of nitric oxide. (239,265,292,296)
  • Improves total antioxidant capacity and stimulates antioxidant defense systems. (33,83,274,276)
  • Superior antioxidant activity and DNA protection in studies comparing against vitamins C, E and beta carotene (vitamin A). (33,272,276)
  • Flavay® increases synthesis of and intracellular levels of superoxide dismutase (Cu/Zn-SOD). (361,369,371,372,373)
  • Flavay® raises intracellular levels of glutathione peroxidase (GPx) including acetylcysteine and improves glutathione reductase activity. (Flavay® is found to improve intracellular glutathione status better than taking a glutathione supplement. Acetylcysteine is a precursor of glutathione in the body.) (361,366,368,369,371,373)
  • Flavay® can double the concentration of superoxide dismutase, catalase and glutathione inside the cells. (361)
  • Protects against free radical release of histamine from mast cells. (35,56,78,146)
  • Inhibits pro-inflammatory cytokine actions. (18,25,61,74,81)
  • In vivo and clinical experiments show that Flavay® decreases cardiac levels of reactive oxygen species (ROS) and malondialdehyde (MDA), a metabolite which forms when ROS and oxidized low density lipoproteins (LDL) attack fatty acids in cell membranes. (438)
How Free Radicals and Oxidation Cause Inflammation
Flavay improves cardiovascular health in multiple ways.
Flavay - International and U.S. Patents and Clinically Proven

Flavay® is patented as a scavenger of the free radicals that play a major role in the degradation of collagen and in the initiation, duration and breakdown of inflammation and in ischemia (reduced blood flow).

“[A] method for preventing and fighting the harmful biological effects of free radicals in the organism of warm blooded animals and more especially human beings, namely cerebral involution, hypoxia following atherosclerosis, cardiac or cerebral infarction, tumour promotion, inflammation, ischemia, alterations of the synovial liquid, collagen degradation, among others.”
—U.S. Patent No. 4,698,360 (1987).

Your blood flows better and your joints hurt less with Flavay®.

For a healthy mind and body

My joints aren't hurting and my back feels better and I'm even able to work better. I'll tell you, I can feel Flavay! —Ms. C.V.*

I have lupus and taking Flavay enables me to move. I'm not able to do without it. I've been taking it for more than a decade and my skin looks younger, in fact people think I'm my kid's sister. —Ms. L.B.*

I just want to say that I love Flavay. When I stop taking it, the pain comes right back. —Mr. Mark H.*

I love your product called Flavay. I feel it does the job! —Mr. Robert B.*

I've got to have my Flavay. Keeps me going. Keeps me young. 4 Flavay every day. —Mr. C.S.*

I had a terrible accident where I fell 20 feet and injured my back and it was really bad. I went from a wheelchair to a cane and now I'm mowing the lawn. Flavay shrank the protruding disk so I could stand up straight again. I've referred many many people to your products, and it worked for them too. —Mr. Dave T.*

Flavay is a product I cannot stop taking. When I stopped taking it for a couple of weeks, my neuropathy and arthritis pain come raging back. So I started again on Flavay and the pain is almost completely gone. —Ms. Elsa D.*

I started taking Flavay for arthritis pain and I feel so much better! I'm so thrilled! —Ms. Susan S.*

After taking Flavay for just a week, my sister is doing things she couldn’t do before, such as bending over to pick things up off the floor. —Mr. Joe C.*

The puffiness in my legs is so much better. Oh my gosh this Flavay is great! —Ms. Joan G.*

Your Flavay really helps my husband's chronic pain syndrome and we're almost out! Please ship asap! —Ms. S.W.*

I was taking Flavay for pain and mobility. Now I take Flavay as much for the benefits to my skin as for joint pain. —Mr. H.S.*

I can’t even tell you how much I appreciated finding your product Flavay and the incredible results and relief I have gotten from taking it... I skeptically ordered two bottles... And low and behold, it works. I read that I could take more than 2 that some people had to take 4 or 5 at a time, so I did, hoping and praying, and my prayers were answered. To say thank-you is an understatement, and I have been able to stop all other pain meds. I honestly was on a one way road to nowhere, now I am free again..a feeling I haven’t had in over 12 years. Thank-you!!!!!!!!!!!!!!! —Ms. Beth B.*

I am a nutritionist and I have referred two of my clients to take Flavay. Both of my clients have raved about the product. One of my clients has a problem with circulation and she said Flavay really works for her. —Mr. John H.*

I've got to have my Flavay. Keeps me going. Keeps me young. 4 Flavay every day. —Mr. C.S.*

My neighbor is so pleased with Flavay telling me how much better she feels. She has heart problems and taking 2 Flavay per day she has so much energy again and her color is better too. —Ms. C.V.*

I have tried everything else and your Flavay really helps my eyesight. I was having trouble seeing at night and now I don't have that problem anymore. I love Flavay. I also had a blown knee that they had wanted to do surgery on and now I don't have to. I love the Flavay, I really like it! —Ms. T.K.*

I start feeling pain in my joints after a few days of not taking Flavay. —Mr. Mark H.*

My daughter has rheumatoid arthritis in her knees and years ago Flavay had really helped her, so I want to order some more for her. —Ms. K.M.*

For several years I took Flavay for fibromyalgia and it really worked and I felt so much better. Now I need to start again. —Ms. C.H.*

I love your product called Flavay. I feel it does the job! —Mr. R.H.*

I have had joint pain in my hips for a couple years. I have been taking Flavay for about 30 days and I realized I don't have hip joint pain when laying down or sitting for long periods! I will continue to take it daily. —Ms. M.H.*

Thank you so much. I'm desperate!! 😊 Haven't taken them (Flavay and Flavay Plus) for a few months and can tell the difference! —Ms. S.A.*

Since I started taking Flavay I felt so good and I'm hoping to keep getting better. I started taking Flavay for my knee but since I started taking Flavay I've cut way back on asthma meds. The medication affects my brain badly. I want to control asthma instead of it controlling me. Flavay is a big help, I am so happy! —Ms. J.I.*

I began giving my daughter Flavay Plus for ADD and then I decided to add Flavay for my daughter's allergies. I want to tell you, the Flavay works like a charm for my daughter’s allergies. She is 6 years old, and when we ran out of capsules this week she told me, “You've got to get more Flavay!” —Ms. S.S.*

I just wanted to write and say WOW... I was so skeptical of your product at first and really had a negative attitude when I started taking it. I am a 40 yr old female with anxiety, mild ADHD and a host of arthritis and inflammation issues. It was a struggle for me to get out of bed everyday and focus on what needed to be done. I had no focus, no attention span, no energy, and no desire to do anything. About a week into taking Flavay and Flavay Plus, I started noticing that I could think a little clearer. My rheumatoid arthritis flare-ups weren't so bad, though I still have them. feeling better, and having more energy. I never thought I would feel like my old self again. I don't know exactly how you do it,...but this stuff works! I am telling all of my friends to try it because you've given me my old life back! Thank you! —Ms. L.A.*

I am not one to review products, but i can't deny some of the benefits i've experienced using both your biomor curcumin and flavay products. I've been taking both for a few months now, and the two major benefits i've noticed are 1) joint strength and mobility (for workouts) as i am lifting much heavier weights without injury 2) I am a paroxsymal Afib sufferer, and my episodes have gone from 2-3 per week down to zero (most weeks). This can't just be a coincidence. I think there is definitely something in your formulas that stop inflammation and get your body in balance and healing itself. —Mr. B.V.W.*

I really notice a difference when taking Flavay Plus, both in inflammation and in my stress levels. —Ms. W.L.*

I'm real happy about Flavay. It seems to have a positive effect on my lymph system. —Ms. R.M.*

* Results vary by person and are not guaranteed. NOTE: We do not compensate for our endorsements and testimonials. We do not consider paid testimonials to be nearly as valuable as comments from customers who were not compensated and yet liked the products so much they gave their testimonials anyway.
†These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.