Flavay is patented as a scavenger of the free radicals that play a major role in the degradation of collagen and in the initiation, duration and breakdown of inflammation and in ischemia (reduced blood flow).

Flavay is the Protector Antioxidant

Flavay® Boosts Antioxidant Levels

How Free Radicals Accelerate
Aging and Disease

"Free radical" molecules constantly work to break down all living cells.

two apple slices, one is beautiful and undamaged by oxidation and the other is ugly and damaged by oxidation.

The corrosive and destructive forces that constantly work to break down all living cells are known as "free radical" molecules. These "radical" molecules damage our cells through attacking the membrane, lipids, tissues' protein, enzymes, carbohydrates and DNA. This oxidative destruction is implicated in aging and degenerative diseases including cardiovascular disease, cataracts, macular degeneration, diabetes, arthritis, Alzheimer's and some liver and kidney diseases. (7,14,346-351,355,356)

Free Radical Molecule causes crosslinking by stealing electrons in proteins (collagen), DNA or any molecule, ion or atom—creating a chain reaction which causes aging and disease. Diagram shows paired electrons, orbitals, nucleus and DNA, and a missing electron which causes the molecule to become a highly-reactive free radical molecule.

What are Free Radicals?

Free radicals are molecules with unpaired electrons. Free radicals steal electrons from neighboring molecules, causing the affected molecule to also become unstable. This chain reaction leads to crosslinking of atomic structures—including proteins (including collagen), enzymes, DNA and RNA. (4,14,171,172,346-351)

Where do they come from?

  1. Some free radicals are good when functioning correctly. For example, our immune system activates white blood cells to create free radicals (like pellets of poison) to destroy invaders by breaking down the genetic material of bacteria, toxins, and viruses. (10,14,202)
  2. But most free radicals are undesirable because they lead to chronic inflammation, arthritis, cognitive problems, accelerated aging and diseases and disorders associated with aging. Harmful sources of free radicals include chemicals in foods and beverages, medications, smoking and vehicle exhaust, and digital "blue light" radiation. (7,14,322,346-351,355,356)

A recent Harvard Health Letter warns that chronic exposure to digital light oxidation (e.g., computers and LED light) is found to cause macular degeneration, glaucoma and retinal degenerative diseases which can eventually cause serious vision loss and blindness. (346-351,355,356)

Free radicals attack and destroy cells and their DNA. Diagram shows free radical steals an electron from DNA and thereby damages DNA.

Every day about 10,000 free radicals attack each cell in our body—and they damage anything and everything in the human cell.

Free Radicals Attack Inside Our Cells

Free radicals damage cells by attacking their various parts and altering cellular functions, causing mutations and cellular deaths, ultimately compromising tissue and organ functions —causing aging and diseases. (355,356)

The type of damage depends on which part of the cell is injured, as discussed below.

  • Mitochondria: Damage to mitochondria depletes the cell's energy supply. Common symptoms include fatigue, muscle weakness, peripheral neuropathy.
  • Lysosomes: When lysosomes are injured, the cell can no longer detoxify itself properly. Enzymes leak out of lysosomes and digest the cell, resulting in inflammation and necrosis (death of the cell).
  • Peroxisomes: Similarly, when peroxisomes are injured, the cell can no longer detoxify itself properly. Like miniature sewage treatment plants, peroxisomes neutralize harmful toxins and carry out lipid metabolism and oxidation reactions that break down fatty acids and amino acids. (Liver cells contain large amounts of peroxisomes.) Damage to peroxisomes is linked to liver dysfunction and neurological dysfunction and degeneration.
  • Endoplasmic Reticulum: Damage to the endoplasmic reticulum is linked to a higher susceptibility for inflammatory processes and cognitive impairment.
  • Cell Membrane: Injury to the cell membrane impairs nutrient delivery and waste removal. Damaged cell membranes leak intracellular proteins into circulation and cause inflammation.
  • Cytoplasm: The cytoplasm gives shape to the cell and holds all the organelles. Injury in cytoplasm impairs the cell's metabolic reactions, including protein synthesis. This is extremely important. Certain proteins act like "spell-checkers" and "proof-readers" and make sure there are no errors (mutations) in the nucleotide sequence before DNA replication.
  • DNA: The most dangerous free radical attack is to the DNA because damage to the DNA causes the cell to replicate abnormally (mutate), or not at all, and die. This type of cell damage is associated to nearly every known disease. (7,346-351,367,370)

Free Radicals Should Not Stay Free:
Antioxidants vs. Free Radicals

The antioxidants work as a network (synergistically) to fight free-radical damage and contribute to health and longevity.

Flavay Improves Endogenous Antioxidant Enzyme Activity. Flavay is shown to boost and protect intracellular antioxidant activities of vitamins C and E, catalase, superoxide dismutase (SOD) and glutathione peroxidase (GPx) Chart shows Nucleus and DNA: vitamin E; Mitochondria: vitamin E and SOD and GPX; Lysosome: vitamins C and E and beta-carotene (vitamin A); Peroxisomes: catalase and GPx; Endoplasmic Reticulum: vitamin E and beta-carotene (vitamin A); Cytoplasm: vitamin C and SOD and GPx; Cell Membrane: vitamin E and beta-carotene (vitamin A); Nuclear Membrane: vitamin E and beta-carotene (vitamin A).

Antioxidants work as a network (not independently) inside the cells and human clinical studies show taking Flavay® significantly increases intracellular serum total antioxidant activity. (10,33,370)

Taking Flavay® as much as doubles plasma levels and activities of vitamins C and E and A, and catalase, superoxide dismutase (SOD) and glutathione (GPx). (33,63,64,71,361,371)

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Free radicals damage DNA. Diagram shows free radical steals an electron from DNA and thereby damages DNA.

The hydroxyl-radical is most dangerous because it can directly attack our DNA. When a free radical steals an electron from DNA in a cell, the cell will die, or lose its ability to replicate, or replicate abnormally (mutation). (7,14,346-351)

Flavay protects DNA from free radical damage. Flavay neutralizes both superoxide and hydroxyl-radicals.

Flavay® protects DNA by neutralizing the hydroxyl-radical and superoxide (superoxide promotes hydroxyl-radical formation). Flavay® is one of the very few antioxidants that can neutralize all varieties of free radicals containing oxygen. The reactive oxygen species are the most energetic and most vicious free radicals. (33,83,274,301,357,360)

Flavay plus a free radical equals a stabilized molecule. Flavay is a radical scavenger and rich electron donor. Free radical is a molecule with a missing electron. Stabilized molecule is now stable because its missing electron is restored. Diagram shows Flavay donating an electron to a free radical to create a stabilized molecule from the free radical.

Flavay® is an electron-rich donor with more reactive sites for neutralizing free-radicals than other antioxidants. Flavay® scavenges a larger quantity and a broader variety of free radicals, transforming free radicals into stable molecules. (1-3,33,271,272,276,282,299)

Flavay regenerates the network antioxidant capacity of vitamins C and E. Flavay is a radical-scavenger with 8 active sites. Vitamin C has 1 active site. Vitamin E has 2 active sites. Diagram shows Flavay donating an electron to vitamin C which then may donate an electron to vitamin E.

Flavay® donates electrons to the body's endogenous antioxidant network and regenerates "used" or "spent" vitamin C, which in turn can regenerate vitamin E. Studies show taking Flavay® substantially increases intracellular antioxidant activities of vitamin C and E and A, catalase, superoxide dismutase (SOD) and glutathione peroxidase (GPx). (33,63,64,71,83,274,361,369,371)

As represented in the diagram above, Flavay® has greater scavenging capacity than vitamins C or E because Flavay® has more available electrons to donate. Inside the cell, Flavay® can trap eight free radicals where vitamin E can trap two and vitamin C can trap only one.

Vitamin C is found more effective in biosynthesis of collagen when in the presence of Flavay®. After vitamin C is recycled by Flavay®, vitamin C may trap another free radical and the cycle continues. This is why a number of research scientists have referred to Flavay® as the co-factor of vitamin C. (33,60,83,274)

Antioxidant and Anti-inflammatory Actions of Flavay. Recycles and improves activities of vitamin C, and protective effects of vitamin E and activity of vitamin A. Protects against lipid peroxidation damage. Highly reactive in both lipid (fat) and aqueous (water) phases of oxidation. Helps balance nitric oxide activity, both to stimulate normal synthesis and inhibit over-production of nitric oxide. Improves total antioxidant capacity and stimulates antioxidant defense systems. Superior antioxidant activity and DNA protection in studies comparing against vitamins C, E and beta carotene (vitamin A).

Patented Antioxidant and
Anti-inflammatory Actions of Flavay®

  • Regenerates and improves intracellular activity of vitamin C and protective effects of vitamin E and activity of vitamin A. (83,33,274,276,63,64,71)
  • Taking Flavay® increases increases vitamin E (a-tocopherol) antioxidant levels in endothelial cells. (292)
  • Clinical studies shows taking Flavay® increases antioxidant capacity of plasma, decreases oxidation of LDL cholesterol and favorably effects lipid profile. (144,145,277,283,284)
  • Clinical studies demonstrate the antioxidant mechanism of Flavay as evidenced by decreased lipid peroxidation of LDL cholesterol. (272)
  • Protects against lipid peroxidation damage. Highly reactive in both lipid (fat) and aqueous (water) phases of oxidation. (277,283,284,299)
  • Helps balance nitric oxide activity, both to stimulate normal synthesis and inhibit over-production of nitric oxide. (239,265,292,296)
  • Improves total antioxidant capacity and stimulates antioxidant defense systems. (33,83,274,276)
  • Superior antioxidant activity and DNA protection in studies comparing against vitamins C, E and beta carotene (vitamin A). (33,272,276)
  • Flavay® increases synthesis of and intracellular levels of superoxide dismutase (Cu/Zn-SOD). (361,369,371,372,373)
  • Flavay® raises intracellular levels of glutathione peroxidase (GPx) including acetylcysteine and improves glutathione reductase activity. (Flavay® is found to improve intracellular glutathione status better than taking a glutathione supplement. Acetylcysteine is a precursor of glutathione in the body.) (361,366,368,369,371,373)
  • Flavay® can double the concentration of superoxide dismutase, catalase and glutathione inside the cells. (361)
  • Protects against free radical release of histamine from mast cells. (35,56,78,146)
  • Inhibits pro-inflammatory cytokine actions. (18,25,61,74,81)
  • In vivo and clinical experiments show that Flavay® decreases cardiac levels of reactive oxygen species (ROS) and malondialdehyde (MDA), a metabolite which forms when ROS and oxidized low density lipoproteins (LDL) attack fatty acids in cell membranes. (438)
Flavay - International and U.S. Patents and Clinically Proven

Flavay® is patented as a scavenger of the free radicals that play a major role in the degradation of collagen and in the initiation, duration and breakdown of inflammation and in ischemia (reduced blood flow).

"[A] method for preventing and fighting the harmful biological effects of free radicals in the organism of warm blooded animals and more especially human beings, namely cerebral involution, hypoxia following atherosclerosis, cardiac or cerebral infarction, tumour promotion, inflammation, ischemia, alterations of the synovial liquid, collagen degradation, among others."
—U.S. Patent No. 4,698,360 (1987).

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How Free Radicals (Oxidation) Cause Inflammation

Flavay® Decreases Inflammation

Inflammation is caused by the overproduction of free radicals in a specific area of the body. The inflammatory response is a factor in arthritis, an umbrella term for more than 100 different diseases that produce either inflammation of the connective tissue (joints and tendons) or degeneration of the articular cartilage (a wearing down of the protective covering that cushions the end of bones, allowing bones to rub together without causing damage to the joints). (7,10)

Flavay® decreases inflammation-produced enzymes which break down collagen in connective tissue of joints. (18,25,61,74,81)

Flavay® decreases inflammation by inhibiting release and synthesis of compounds that promote inflammation, including histamine, serine proteases, prostaglandins and leukotrienes. (18,25,61,74,81)

Anti-inflammatory activity of Flavay: Flavay protects against unfavorable free-radical release of histamine. Cycle shows: 1 Free radical activator. 2 Flavay protects inactive hyaluronidase. 3 results in reduction of hyaluronidase activation. 4 which protects inactive histamine. 5 which reduces histamine activation. 6. which reduces inflammation and allergic response.

Flavay® lowers the inflammatory and allergic activity of histamine by protecting inert hyaluronidase enzymes from activation by oxidation. (Hyaluronidase activation also breaks down the hyaluronic acid in connective tissue.) Researchers noted Flavay® has both anti-inflammatory and anti-allergic activity. (3,35,56,78,146)

Flavay® selectively binds to collagen in connective tissue of joints, preventing inflammation and lessening pain. (18,25,60,61,74,81)

A six-month double-blind, randomized, placebo-controlled study of women recovering from breast surgery found Flavay® improved pain, skin tension and flexibility in movement. (82)

Various studies show Flavay® mediates nitric oxide activities and modulates the activity of the enzymes thromboxane A2, cyclooxygenase (COX-1 and COX-2), 5-lipoxygenase, and other inflammatory-causing compounds. Most importantly, this protection comes without the side effects common to NSAIDs. (53,230,265,274,292,296,302)

Free Radicals are the 'Link'
to Aging and Disease

One of the clearest manifestations of free radical damage is over-crosslinking, which is where free radicals reactions cause proteins and/or DNA molecules to fuse together. Over-crosslinking damages proteins (including collagen), enzymes, DNA and RNA. (9)

Over-crosslinking makes collagen inflexible and non-functional and contributes to degeneration and accompanying diseases. (4,14,346-351)

Flavay® binds to collagen fibers and realigns them to a more youthful form. (18,19,60)

  • Skin: In skin cells, over-crosslinking causes saggy skin and wrinkles. (346-348)
  • Vessels: Over-crosslinking makes vessels brittle and leaky, causing inflammation, swelling and poor blood flow. (346-351)
  • Eyes: Over-crosslinking causes fragile vessels which leads to reduced retinal blood flow and ultimately inflammation; may include hemorrhages, microaneurysms, and exudates (oozing fluids). Bleeding and leaking from the damaged vessels eventually causes vision loss and blindness. (346-351)
  • Cardiovascular: In arterial cells, over-crosslinking reduces flexibility which raises blood pressure and puts extra strain on the heart as it pumps harder to maintain a continuous flow of blood. (346-351)
  • Joints: Over-crosslinking causes connective tissue to become stiff, swollen and painful. (346-351)
  • Brain: In the brain, over-crosslinking impedes message transmission between nerve cells so thinking processes slow down and cause concentration and memory problems. (4,14,346-351)
  • DNA: Damage to the DNA causes the cell to replicate abnormally (mutate), or not at all, and die. This type of cell damage is associated to nearly every known disease. (7,346-351,367,370)

Through synergistic action with vitamin C, Flavay® strengthens and rebuilds the body's natural collagen proteins and has the remarkable ability to reactivate collagen and elastin. Research demonstrates Flavay® binds to collagen fibers and realigns them to a more youthful, undamaged form. (Pure vitamin C is less effective in synthesis of collagen when the phytonutrients of Flavay® are missing. The same research also established that common bioflavonoids are completely inactive in this respect.) (18,19,23,60,266-268)

too much crosslinking in collagen polypeptides causes leaky vessels and saggy skin

Studies show Flavay® improves the beneficial crosslinking between amino acids of the fibers that give collagen its flexibility and strength while preventing the undesirable over-crosslinking that weakens collagen. Laboratory tests found Flavay® reduced degradation of elastin fibers by up to 70 percent. (18,19,23,60,266-268)

Free Radical Molecule causes crosslinking by stealing electrons in proteins (collagen), DNA or any molecule, ion or atom—creating a chain reaction which causes aging and disease. Diagram shows paired electrons, orbitals, nucleus and DNA, and a missing electron which causes the molecule to become a highly-reactive free radical molecule.

Free radicals cause crosslinking damage in collagen molecules which leads to accelerated aging, leaky vessels and saggy skin.

Flavay® scavenges the free radicals which cause premature aging by renewing, strengthening and protecting collagen throughout the body. (44-48,60,69-72,250,270)

How Crosslinking Leads to Aging and Decay

Over-crosslinking damages proteins (including collagen), enzymes, DNA and RNA. (4,14,171,172,346-351)

Over-crosslinking makes collagen inflexible and non-functional and contributes to degeneration and accompanying diseases. (4,14,171,172,346-351)

  • Skin: In skin cells, over-crosslinking causes saggy skin and wrinkles. (346-348)
  • Vessels: Over-crosslinking makes vessels brittle and leaky, causing inflammation, swelling and poor blood flow. (346-351)
  • Cardiovascular: In arterial cells, over-crosslinking reduces flexibility which raises blood pressure and puts extra strain on the heart as it pumps harder to maintain a continuous flow of blood. (346-351)

Flavay® selectively binds to collagen in connective tissue of joints, preventing inflammation and lessening pain. (18,25,60,61,74,81)

  • Eyes: Over-crosslinking causes fragile vessels which leads to reduced retinal blood flow and ultimately inflammation; may include hemorrhages, microaneurysms, and exudates (oozing fluids). Bleeding and leaking from the damaged vessels eventually causes vision loss and blindness. (346-351)
  • Joints: Over-crosslinking causes connective tissue to become stiff, swollen and painful. (346-351)
  • Brain: In the brain, over-crosslinking impedes message transmission between nerve cells so thinking processes slow down and cause concentration and memory problems. (4,14,346-351)
  • DNA: Crosslinking damage to DNA leads to cell mutation and disease. (7,346-351,367,370)
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Free Radicals and Cardiovascular Function

Free radicals are involved in the progression of heart disease in several different ways. Heart disease begins with the oxidation of LDL (low-density lipoproteins) cholesterol which leads to the formation of plaque in the arteries. If an artery becomes clogged with plaque, the result can be a heart attack (a sudden loss of blood and oxygen to the heart) or a stroke (loss of blood to the brain). Much of the damage that occurs in both heart attacks and strokes is caused by reperfusion injury, the burst of superoxide free radicals that surge in as blood flow resumes. (3,8,10)

Flavay® Improves Endothelial Function and Boosts Nitric Oxide Levels

Nitric oxide is essential for normal blood circulation as it controls the muscular tone of blood vessels and regulates circulation and blood flow. However, nitric oxide is a free radical and excessive amounts of nitric oxide can be deadly to the cardiovascular system and actually contribute to heart disease and strokes, and many other apparently different disorders (such as arthritis, asthma and Alzheimer's disease). So, in order to have good circulatory health, the body must maintain the right balance of nitric oxide—and that's the role of Flavay®. (10,239,265,292,296)

Flavay® aids in production of endothelial nitric oxide which helps to dilate blood vessels and causes blood platelets return to their normal smooth condition. (10,239,265,292,296)

Flavay® is shown to improve vasodilation and mildly inhibit angiotensin-converting enzyme (ACE) by modulating nitric oxide metabolism in endothelial cells. (292,296)

Flavay® Strengthens Vessels and Increases Blood Flow

Over 70 years of scientific and clinical research establishes that Flavay® strengthens collagen in vascular walls and capillaries and thereby makes the vessels stronger and more elastic. Flavay® is shown to increase capillary resistance, decrease capillary permeability, and increase rate of lymph flow. (47,48,60,82,205)

Free Radicals and Cognitive Function

Free radicals are created when our bodies fight an infection. The immune system's cytokines go to work, sending messages to the brain that cause more white blood cells to mobilize. The more white blood cells the body activates, the more free radicals they produce, like pellets of poison, that go to work to destroy invaders by breaking down the genetic material of bacteria, toxins, and viruses. (14)

Unfortunately, free radicals can interfere with the biological components of our healthy cells in the same way they destroy invaders, literally dismantling the body's essential cellular proteins, fatty cell membranes and DNA. (7,14,346-351)

Some free radicals are beneficial when functioning properly. Nitric oxide and histamine are free radicals which act as neurotransmitters and immuno-transmitters when functioning correctly. In fact, nitric oxide and histamine are now recognized as very important signaling molecules for intercellular and intracellular communication throughout the body. (14,102,232-236,248,352,353,377)

All higher brain functions require a well-balanced release of nitric oxide in the brain. Nitric oxide also plays a major role in the function of the blood-brain barrier, as it consists mainly of microvascular endothelial cells which are regulated by nitric oxide. (202-204,374)

Excessive production of nitric oxide and histamine can cause some of the brain's worst free radical damage and development of neurological diseases. (10,14,202-204,352,353,377,379-384)

Protection of nitric oxide activity by Flavay® is important to brain functions because when nitric oxide is over-produced, a chain reaction begins which causes neurons to break down and destroy surrounding healthy cells. In Alzheimer's, free radicals attack cell membranes of the hippocampus, the memory region. In Parkinson's disease, the area of the brain to suffer the most damage is the "substantia nigra," which produces dopamine, the neurotransmitter responsible for muscle movement and coordination. (14,232-236,240-242)

Flavay® protects against free radical release of histamine and helps balance nitric oxide activity, both to stimulate normal synthesis and inhibit over-production of nitric oxide. (239,265,292,296)

In modulating nitric oxide levels, Flavay® helps improve concentration, learning and memory. (14,53,103,202-204,265,274)

Light, Oxidation and Vision Loss

Due to the exposure to light and oxygen, the oxidative stress burden is higher in the eye than other tissues. Oxidative damage in responsible for macular degeneration, glaucoma, retinal degeneration and retinopathies, and cataracts. Our eyes (which are 80% collagen) rely on specialized aqueous (water) and lipid (fat) barriers for protection. But, our body's antioxidant mechanisms become progressively less effective as we age. (323-327)

Flavay® Protects Retinal Cells From Oxidation

The hallmark of optic neurodegenerative diseases (including retinopathy and glaucoma) is retinal ganglion cell-death. Studies show Flavay® protects oxidative stress-injured retinal ganglion cells by inhibiting apoptosis (cell-death). (257-259,299)

A number of epidemiologic studies have found that persons with age-related eye diseases had significantly lower levels of antioxidants, particularly vitamin C, than did persons who did not develop those eye conditions. Research shows Flavay® increases intracellular levels of vitamin C and E, and enhances the activity of vitamin A in human eyes. Also, Flavay® provides its own powerful antioxidant protection to the eyes and its tiny blood vessels. (1,81,63,64,71,202,260)

In clinical trials of persons with various types of retinal degenerations, including macular degeneration, diabetic retinopathy, retinitis pigmentosa, and hemorrhagic and hypertensive retinopathy, all persons taking Flavay® showed significant improvement. (69-72)

Other clinical studies show Flavay® significantly improves (both objectively and subjectively) light-dark vision impairment in persons who work at computer monitors and persons who drive at night. (63,64,65,71,262,263)

Flavay® is found to increase visual acuity in light-dark adaptations and recovery from glare by increasing the rate of rhodopsin regeneration (an important function of vitamin A). (63-65,71,262,263)

Flavay® is your best protection against "blue light" damage to your eyes. Licensed in France for for use in diabetic retinopathy, Flavay® should be part of the daily nutritional regimen of every aging person (most especially every diabetic person).

man looking at computer shows reflection of light in his glasses

Clinical trials found taking Flavay® significantly improved retinal sensitivity and recovery after glare in persons with healthy eyes working at computers. (63-65,71,262,263)

Change the way you grow older by protecting your brain cells and your vision for the many years ahead.

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