Have proper research studies proven the safety and effectiveness of Flavay? And other frequently asked questions.

Frequently Asked Questions

Frequently Asked Questions


What is Flavay®?


Flavay - International and U.S. Patents and Clinically Proven

Flavay® is a highly specialized, nutritional complex of singles, pairs and triples of a specific molecule called flavan-3-ol, isolated from natural extracts which has been extensively tested and examined clinically for biological antioxidant protection, collagen strengthening, tissue rebuilding, reducing inflammation, improving circulation and cognitive function, and other health producing outcomes. See: What Can Flavay® Do For Your Body?

Flavay® is manufactured using patented processes.

The science behind Flavay® is very complex. Where its single molecules are highly beneficial, the same molecules would be non-nutritive (and have pro-oxidant activity) if they were isolated from their natural partners. So, organic groups of single and small-clusters of specific molecules are selectively preserved while anti-nutritive large-clusters of molecules are removed. Also, native organic acids are retained to protect the otherwise perishable bioactivity, and for other significant benefits. See: Molecular Composition of Flavay®


How safe is Flavay®?


After more than 65 years of human use, no adverse effects have been observed. Furthermore, intensive biological, toxicological, pharmacological and analytical research was conducted for the purpose of registration as a medicine in France and other countries in Europe. In one study, the equivalent of daily doses of up to 35,000 mg for six months were determined to cause no adverse effects. See: Proven Safety of Flavay®

Rigorous testing and many decades of human use have proven Flavay® is very safe for all ages. (1,90-94)
Licensed, patented and sold in France since 1950, the vascular (veins, arteries, capillaries and lymph) protective activity of Flavay® has been established by many significant studies. (3,38-54)


How does Flavay® affect the kidneys and liver?


Flavay® is shown to protect and benefit the kidneys and liver.

Studies show Flavay® supplementation is beneficial in preventing hepatic (liver) and renal (kidney) toxicity in instances of acetaminophen and other drug poisonings. This protection was attributed to detoxification of cytotoxic free radicals and facilitation of DNA repair. Researchers found Flavay® improved blood urea nitrogen and serum creatinine; histological improvement was also noted. (309-311)

Flavay® protects the small vessels in the liver. A double-blind placebo-controlled trial of persons with hepatic (liver) cirrhosis, found Flavay® (300 mg daily) significantly reduced capillary fragility. (45)


Does Flavay® have any contraindications?


No. Flavay® has no known contraindications (conditions under which it should not be used). Flavay® is completely safe and nontoxic. In fact, clinical trials have been conducted in which pregnant women (troubled by varicose veins and other circulatory problems in the legs) safely used Flavay®. (1-3,90-94)

There are no known interactions between Flavay® and other medications. However, if you are taking anticoagulant drugs, be aware that Flavay® is shown to favorably normalize reactivity (“stickiness”) of blood platelets. Notify your physician as dosing adjustments may be advised.


Should I consult with my doctor before taking Flavay®?


Yes, always consult your doctor before starting any course of supplementation or diet change if you are under medical care. If you have or suspect you may have a health problem, you should consult your doctor.


Can the active ingredients in Flavay® be obtained in food?


Not in our modern diet. In most cases, industrially-produced food no longer contains the active ingredients in Flavay®.

Why can’t we rely on our diet?

There are a number of reasons. First, the vital oligomeric proanthocyanidins (OPCs) are found mostly in seeds, barks, shells, peels and woody parts which are typically removed before eating. All canned foods are peeled and pitted. Fruit and vegetable nutrition is stripped in industrial processing. Even fresh fruits and vegetables are missing these essential nutrients because they are picked before full maturation.

  1. Fresh fruits and vegetables are prematurely harvested.
  2. Industrially-produced food lacks vital nutrients.
  3. Modern factors that increase oxidative stress are: smoke, smog, chemical pollution, pesticides, herbicides and synthetic preservatives and additives in our food, and medications. Modern high-efficiency light and pervasive noise are also shown to cause damaging oxidative stress in the eyes, ears and brain.
When picked before full maturity, fruits and vegetables lack vital antioxidant nutrients.
A German study found that unless they are fully-vine-ripened and fully-tree-ripened, even fresh vegetables and fruits contain very low levels of the active principles in Flavay®. (293)

The active ingredients in Flavay® are at the center of the curious phenomenon known as the “French Paradox.” So, why not just drink red wine to get your daily dose of Flavay®? Alcoholic beverages are not ideal due to potential abuse, dependency and toxicity from over-consumption. Also, alcohol can compromise liver function but Flavay® actually helps protect hepatic capillaries (the smallest blood vessels in the liver) from free radical damage and activates liver antioxidant enzyme systems. (45,309-311)

The point is that Flavay® provides specific protection to the liver, and red wine does not. So, while drinking some red wine is a reasonably healthy for most adults, the best way to guarantee a consistent daily intake of OPCs is in its pure, concentrated form—Flavay®.

Fresh Fruits and Vegetables are Prematurely Harvested

The fresh fruits and vegetables at the supermarkets are deficient in OPCs because mass food production doesn’t allow for fruits and vegetables to fully ripen on the tree or vine. Modern food distribution requires premature harvesting to allow for time in transportation, packaging, distribution and purchase by the final consumer.

There are very few OPCs in unripened fruits and vegetables. A German study proved that the quantity of OPCs in the fruit increases as the fruit matures on the tree or vine. The study found fresh fruits and vegetables must fully mature on the tree or vine before plants create OPCs. (293)

Unfortunately, modern food distribution requires premature harvesting so our food is deficient in vital nutrients.

Industrially-Produced Food Lacks Vital Nutrients

Industrially-produced food, in most cases, no longer contains the parts of plants rich in OPCs. Canned foods are peeled and pitted. Furthermore, nutrition in fruits and vegetables is stripped by industrial processing. Even fresh fruits and vegetables are missing vital flavanols because they are picked before full maturation.

In most cases, industrially-produced food contains none of the active principles in Flavay®

Modern-Living Causes Oxidative Stress

Last, but not least, oxidative stress in modern living shows the need for more antioxidant protection. Common sources of oxidation include smoke, smog, chemical pollution, pesticides, herbicides and synthetic preservatives and additives in our food, and medications.

High-efficiency “blue” light causes oxidative stress in eyes: A recent Harvard Health Letter warns that chronic exposure to oxidative high-energy visible (HEV) or “blue” light may lead to macular degeneration, glaucoma, and retinal degenerative diseases which can eventually cause serious vision loss. (322)

Pervasive noise causes oxidative damage in the ears and brain: Pervasive noise is common in most modern communities and work environments. Its damaging effects, particularly the production of free radicals, are not limited to the auditory organ. Researchers found broadband white noise (100 dB) exposure significantly increased oxidation in brain regions. (197,198)

Protect your organs by supplementing with Flavay® daily.

Flavay® is your best protection against oxidative damage to your eyes caused by high-energy visible light.


Is Flavay® patented?


Yes, Flavay® is manufactured using patented processes.

  • 1948-1951: French patents described methods to extract the active principles in Flavay® for the protection of the vascular system.
  • 1964-1965: French patents for increasing efficiency of the manufacturing process, and a medicine patent for vascular protection.
  • 1969: U.S. Patent No. 3,436,407 for manufacturing and for vascular protection.
  • 1970: a new French patent for manufacturing in a state of purity that conforms with French pharmacopoeia standards.
  • 1987: U.S. Patent No. 4,698,360 to describe the powerful antioxidant properties known as the “radical scavenger effect.”

There are more patents, most are French.

Flavay: International and U.S. Patents and Clinically Proven

Flavay® is patented as a scavenger of the free radicals that play a major role in the degradation of collagen and in the initiation, duration and breakdown of inflammation and in ischemia (reduced blood flow).

“[A] method for preventing and fighting the harmful biological effects of free radicals in the organism of warm blooded animals and more especially human beings, namely cerebral involution, hypoxia following atherosclerosis, cardiac or cerebral infarction, tumour promotion, inflammation, ischemia, alterations of the synovial liquid, collagen degradation, among others.”
—U.S. Patent No. 4,698,360 (1987).


Have proper research studies proven the effectiveness of Flavay®


Yes. Flavay® is backed by 65 years of scientific research, patents, clinical studies, and extensive testing for safety.

Registered in France since 1950 for use in over-the-counter medications, Flavay® has therefore been consumed in Europe under medical supervision for decades with no reports of adverse side effects.

Flavay: 65 years of science


Is Flavay® a bioflavonoid?



Some bioflavonoids are toxic and some are inefficacious. Bioflavonoids have very poor bioavailability or none at all. Flavonoids is a very complex category and nearly 20,000 different flavonoids have been characterized. (2-4,89,178,180)

Bioflavonoids are made of a different species of molecule than Flavay®. Bioflavonoids are made of molecules known as “flavonols” (note the “o”). (2-4,89,178)

Flavay® is comprised of molecules known as flavanols (note the “a”) which are part of very specifically defined small organic molecular cluster-complexes. (1-4,89)

Major differences between Flavay® and bioflavonoids:

  1. Flavay® binds to proteins (collagen and elastin)—bioflavonoids do not.
  2. Flavay® is highly bioavailable and bioactive—bioflavonoids have very poor bioavailability or none at all.
  3. Flavay® is proven very safe—many bioflavonoids are unsafe.
Binds to collagen? Biologically Active? Non-Toxic and Safe?

Very Poor or None

Some are Toxic


SMALL cluster




LARGE cluster



“Certain bioflavonoids are mutagenic at high doses.”

—Jack Masquelier, et. al, “Flavonoides et pycnogenols,” Int. J. Vit. Nutr. Res.; 1979. (89)

Bioflavonoids sold in high doses, including “grape seed extracts” are “likely to make you sick.”

—“Beware of plant supplements called flavonoids; they could make you sick, warn UC Berkeley public health experts.” Free Radical Bio. & Med.; 2000. (194)


What is the difference between OPCs and polyphenols?

“What is the difference between the terms, OPCs and polyphenols? In some cases it appears synonymous and in others there appears to be a distinction. On some labels it will say OPCs, but in the supplement facts, it says grape seed extract (vitis vinifera) 95% polyphenols. I am confused.”


It's confusing because these terms are often used inaccurately for commercial interests—or by mistake. “95% polyphenols” is a meaningless expression on a supplement label. However, it does illustrate a problem. In most cases, the following terms are used inaccurately and have truly lost all scientific meaning in the marketplace (including product labels, magazine and internet articles, and many popular books).

The following terms are used interchangeably for commercial interests—or by mistake—and their differences have truly lost all scientific meaning in the marketplace:
  • polyphenols
  • proanthocyanidins (procyanidins)
  • oligomeric proanthocyanidins (OPCs or PCOs)
  • bioflavonoids
  • flavonoids
diagram of phenol

What are Polyphenols?

Polyphenols are chemicals (derived from plants or petroleum) with a phenol structure (shape).

Polyphenols is a very broad and extremely complex group of chemicals. The term is widely used ambiguously and confusingly, but generally refers to natural chemicals with phenol structural units—with lack of consideration to solubility (ability to dissolve), precipitation (ability to vaporize), and complexation (bonding) phenomena. (188)

Many plant-derived polyphenols are antinutritive— which means they interfere with absorption of nutrients with toxic effects. For example, flavonoids are polyphenols which are related by their pigment (color) and certain flavonoids are known to be mutagenic and can be dangerous to your health. (89,189-194)

Most polyphenols are unhealthy for consumption.

  • Petroleum-derived phenols are used in producing polycarbonates, epoxies, nylon, detergents, and herbicides.
  • Many plant-derived polyphenols are nonnutritive or antinutritive, or toxic. Some polyphenols are shown to be carcinogenic/genotoxic and mutagenic. (89,189)


Are OPCs the same as grape seed or pine bark extract?


No, but the marketplace wrongly uses the terms interchangeably.

Because of commercial interests—or by mistake— the terms, OPCs and proanthocyanidins, have truly lost all of their scientific meaning in the marketplace. In most cases, suppliers and retailers confuse grape seed extracts as being synonymous with OPCs or proanthocyanidins.

At the University of British Columbia, an academic comparative analysis found commercially-produced OPCs “differed substantially... shown to be only 7.2% similar... raising questions about its quantification in units of [antioxidant] activity” and confirming that standardized quantification of OPCs does not exist in the marketplace. (179)


Is Flavay® the same as grape seed or pine bark extract?



“Grape seed extract” (and “pine bark extract”) is a vague, nonspecific term which really has no scientific value. In fact, crude “grape seed extract” (and “pine bark extract”) imitations are virtually worthless to the consumer without active and naturally-derived oligomeric proanthocyanidins with antioxidant capacity. Some of these extracts contain nothing more than grape seeds or other plant parts which have been pulverized in a food processor.

There is no relevant pharmaceutical, nutritional, biochemical or analytical definition of “grape seed extract” (and “pine bark extract”) nor is there one standardized manufacturing method. There are no commonly accepted, clear analytical “fingerprints” for qualifying grape seed extract (or pine bark extract). In fact the term is so broad and so vague that “grape seed extract” (and “pine bark extract”) can and does mean just about anything.


Is Flavay® the same as OPCs (oligomeric proanthocyanidins) in the marketplace?



Other “OPCs” products contain unidentified and untraceable extracts typically labeled vaguely as “grape seed extract” or “pine bark extract.” Even a trained observer is left guessing about the origin of the ingredients, method of production, and in which country and according to what standards it was produced.

Let the buyer be aware: There is no American industry standard for accurately identifying and quantifying products sold as OPCs in the marketplace.

Other so-called “OPCs” products contain unidentified and untraceable extracts typically labeled vaguely as “grape seed extract” or “pine bark extract.”
Even a trained observer is left guessing about the origin of the ingredients, method of production, and in which country and according to what standards it was produced.

Consumers should also be aware that some manufacturers of grape seed and pine bark extracts have devised ways to artificially boost the proanthocyanidin numbers for their extracts in a test tube (in vitro, which is outside the living body and in an artificial environment). However, there is no scientific research to show whether the human body benefits from this artificial boost.

More importantly, large-clusters of proanthocyanidins are antinutritive and unhealthy for consumption. The large proanthocyanidins cause proteins and nutrients to become indigestible and result in toxic effects. (189-194)

Large proanthocyanidins are unhealthy for consumption because they bind to and prevent absorption of useful nutrients. (189-194)

Flavay® is Proven Safe and Therapeutic

Flavay® is manufactured under the control of pharmaceutical inspection by the French Ministry of Health.

Patented Manufacturing Processes

More than 65 years of scientific research, patents and clinical studies, rigorous manufacturing controls and comprehensive identity-testing to safeguard the quality and consistency of Flavay®.


Do you have questions?

For a healthy mind and body

My joints aren't hurting and my back feels better and I'm even able to work better. I'll tell you, I can feel Flavay! —Ms. C.V.*

I have lupus and taking Flavay enables me to move. I'm not able to do without it. I've been taking it for more than a decade and my skin looks younger, in fact people think I'm my kid's sister. —Ms. L.B.*

I just want to say that I love Flavay. When I stop taking it, the pain comes right back. —Mr. Mark H.*

I love your product called Flavay. I feel it does the job! —Mr. Robert B.*

I've got to have my Flavay. Keeps me going. Keeps me young. 4 Flavay every day. —Mr. C.S.*

I had a terrible accident where I fell 20 feet and injured my back and it was really bad. Taking Flavay has made me so much better and now I have no back problem whatsoever. I mowed my yard today. I've referred many many people to your products, and it worked for them too. —Mr. Dave T.*

Flavay is a product I cannot stop taking. When I stopped taking it for a couple of weeks, my neuropathy and arthritis pain come raging back. So I started again on Flavay and the pain is almost completely gone. —Ms. Elsa D.*

I started taking Flavay for arthritis pain and I feel so much better! I'm so thrilled! —Ms. Susan S.*

After taking Flavay for just a week, my sister is doing things she couldn’t do before, such as bending over to pick things up off the floor. —Mr. Joe C.*

The puffiness in my legs is so much better. Oh my gosh this Flavay is great! —Ms. Joan G.*

Your Flavay really helps my husband's chronic pain syndrome and we're almost out! Please ship asap! —Ms. S.W.*

I was taking Flavay for pain and mobility. Now I take Flavay as much for the benefits to my skin as for joint pain. —Mr. H.S.*

I can’t even tell you how much I appreciated finding your product Flavay and the incredible results and relief I have gotten from taking it... I skeptically ordered two bottles... And low and behold, it works. I read that I could take more than 2 that some people had to take 4 or 5 at a time, so I did, hoping and praying, and my prayers were answered. To say thank-you is an understatement, and I have been able to stop all other pain meds. I honestly was on a one way road to nowhere, now I am free again..a feeling I haven’t had in over 12 years. Thank-you!!!!!!!!!!!!!!! —Ms. Beth B.*

I am a nutritionist and I have referred two of my clients to take Flavay. Both of my clients have raved about the product. One of my clients has a problem with circulation and she said Flavay really works for her. —Mr. John H.*

I've got to have my Flavay. Keeps me going. Keeps me young. 4 Flavay every day. —Mr. C.S.*

My neighbor is so pleased with Flavay telling me how much better she feels. She has heart problems and taking 2 Flavay per day she has so much energy again and her color is better too. —Ms. C.V.*

I have tried everything else and your Flavay really helps my eyesight. I was having trouble seeing at night and now I don't have that problem anymore. I love Flavay. I also had a blown knee that they had wanted to do surgery on and now I don't have to. I love the Flavay, I really like it! —Ms. T.K.*

I start feeling pain in my joints after a few days of not taking Flavay. —Mr. Mark H.*

My daughter has rheumatoid arthritis in her knees and years ago Flavay had really helped her, so I want to order some more for her. —Ms. K.M.*

For several years I took Flavay for fibromyalgia and it really worked and I felt so much better. Now I need to start again. —Ms. C.H.*

I love your product called Flavay. I feel it does the job! —Mr. R.H.*

I have had joint pain in my hips for a couple years. I have been taking Flavay for about 30 days and I realized I don't have hip joint pain when laying down or sitting for long periods! I will continue to take it daily. —Ms. M.H.*

Thank you so much. I'm desperate!! 😊 Haven't taken them (Flavay and Flavay Plus) for a few months and can tell the difference! —Ms. S.A.*

Since I started taking Flavay I felt so good and I'm hoping to keep getting better. I started taking Flavay for my knee but since I started taking Flavay I've cut way back on asthma meds. The medication affects my brain badly. I want to control asthma instead of it controlling me. Flavay is a big help, I am so happy! —Ms. J.I.*

I began giving my daughter Flavay Plus for ADD and then I decided to add Flavay for my daughter's allergies. I want to tell you, the Flavay works like a charm for my daughter’s allergies. She is 6 years old, and when we ran out of capsules this week she told me, “You've got to get more Flavay!” —Ms. S.S.*

I just wanted to write and say WOW... I was so skeptical of your product at first and really had a negative attitude when I started taking it. I am a 40 yr old female with anxiety, mild ADHD and a host of arthritis and inflammation issues. It was a struggle for me to get out of bed everyday and focus on what needed to be done. I had no focus, no attention span, no energy, and no desire to do anything. About a week into taking Flavay and Flavay Plus, I started noticing that I could think a little clearer. My rheumatoid arthritis flare-ups weren't so bad, though I still have them. feeling better, and having more energy. I never thought I would feel like my old self again. I don't know exactly how you do it,...but this stuff works! I am telling all of my friends to try it because you've given me my old life back! Thank you! —Ms. L.A.*

I am not one to review products, but i can't deny some of the benefits i've experienced using both your biomor curcumin and flavay products. I've been taking both for a few months now, and the two major benefits i've noticed are 1) joint strength and mobility (for workouts) as i am lifting much heavier weights without injury 2) I am a paroxsymal Afib sufferer, and my episodes have gone from 2-3 per week down to zero (most weeks). This can't just be a coincidence. I think there is definitely something in your formulas that stop inflammation and get your body in balance and healing itself. —Mr. B.V.W.*

I really notice a difference when taking Flavay Plus, both in inflammation and in my stress levels. —Ms. W.L.*

* Results vary by person and are not guaranteed. NOTE: We do not compensate for our endorsements and testimonials. We do not consider paid testimonials to be nearly as valuable as comments from customers who were not compensated and yet liked the products so much they gave their testimonials anyway.
†These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.