Flavay improves red blood cell membranes so they remain flexible.

Improve Blood Cell Flexibility with Flavay

Restore Flexibility of Red Blood Cells

Oxidative stress and inflammation cause damage to red blood cells.

Red blood cells (erythrocytes) are extremely sensitive cells because, during inflammation, whether it is systemic or chronic, the blood is constantly exposed to circulating inflammatory mediators. Red blood cells have a highly specialized and organized membrane structure, which interacts and reacts to inflammatory molecule insults, and undergo programmed cell death, similar to apoptosis, known as eryptosis. (392)

Oxidative stress is an important accelerant and inducer of eryptosis (cellular death). Oxidative stress plays a key role in the progression of type 2 diabetes and affects the red blood cell membrane. Healthy cells have a large amount of glutathione (GPx) to buffer the damaging effects oxidative stress. (182,392)

Flavay® protects blood cell membranes by as much as doubling intracellular levels and activities of glutathione (GPx). (33,64,64,71,361,371)

Flavay® Favorably Increases Erythrocyte Deformability

Flavay® strengthens and protects red blood cells.

As Flavay® strengthens connective tissue in vessel walls, studies show Flavay® improves the membrane protein structure of red blood cells so they can flex and change shape during circulation. Red blood cells must change shape extensively without rupturing for micro-circulation. Human clinical trials of persons with diabetes show Flavay® increases erythrocyte (red blood cell) deformability (flexibility) without increasing viscosity (resistance). (70,182,183)

Red blood cells must change shape extensively without rupturing for good blood flow. Flavay® improves red blood cell membranes so they are flexible and "deformable." (70,182,183)

A trial of 15 subjects with diabetes assessed the effect of Flavay® on blood flow rate and blood viscosity by measuring erythrocyte deformability by filterability index. After six weeks of taking Flavay® (400 mg per day) the average erythrocyte deformability index markedly increased. The blood viscosity remained unchanged. By increasing erythrocyte deformability, the blood flow rate improved. (70)

A study of 80 subjects divided into two control groups consisting of 20 healthy volunteers and 60 volunteers with poorly-controlled type-2 diabetes. Researchers examined the red blood cell membrane structure and shape changes of blood before and after treatments. (52% of the diabetic group were also taking anticoagulant medications. 67% of the diabetic group were taking anticholesterol medication. 73% of the diabetic group were also taking antihypertensive medications. 97% of the diabetic group were also taking hypoglycaemic medications. There were no interactions with the medications.) Results show taking Flavay® (daily doses of 200 mg) significantly improves the deformability and membrane protein structure of red blood cells in type-2 diabetics and positively contributes to red blood cell functioning. (182)

An in vitro study shows Flavay® increases red blood cell membrane fluidity, potentially owing to inducing modification of the lipid bilayer and lipid-protein interactions. This research shows Flavay® can significantly increase membrane fluidity especially at the membrane surface as compared with untreated red blood cells. Flavay® is shown to have protective effects against lipid peroxidation, generation of thiobarbituric acid reactive products and oxidative hemolysis. Flavay® reduces the lipid peroxidation and oxidative hemolysis either by reducing free radicals or by chelating metal ions, or by both. (183)

A double-blind, randomized, placebo-controlled intervention study with 28 male smokers with 200 mg per day of Flavay®. At baseline, after 4 and 8 weeks researchers measured macro- and microvascular function and a cluster of systemic biomarkers for major pathological processes occurring in the vasculature: disturbances in lipid metabolism and cellular redox balance, and activation of inflammatory cells.

In the Flavay® group, serum total cholesterol and LDL decreased significantly by 5% and 7%, respectively in volunteers with elevated baseline levels. Additionally, after 8 weeks the ratio of glutathione to glutathione disulphide in erythrocytes rose from baseline by 22% the Flavay® group. Researchers observed that Flavay® supplementation exerts anti-inflammatory effects in blood towards ex vivo added bacterial endotoxin and significantly reduces expression of inflammatory genes in leukocytes and noted a "significant improvement of overall vascular health" in the Flavay® group. (454)

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