Studies show Flavay® improves the nitric oxide levels produced in vessels walls and thereby causes the platelets to return back to their normal smooth (unsticky) condition. By the same action, the muscles surrounding blood vessels relax (endothelial vasodilation) and blood flow improves. (50,264,265,292,302,306,397)
Research shows Flavay® is particularly effective against increased platelet aggregation (stickiness and increased clotting tendency) caused by smoking. (53,264,265,292,302,306)
Blood platelets are colorless blood cells. When activated, platelets release protein chemicals which cause the platelets and vessel walls to become sticky and lead to clotting. (386)
A large and growing body of evidence shows that platelet activation is not a result of inflammation but a central part of the inflammatory process itself. Scientists have identified "cross-talk" between platelets, vascular endothelium (cells lining vessel walls) and leucocytes (white blood cells) in response to inflammatory stimuli. (399)
Experiments show Flavay® stimulates the inhibitory receptor PECAM-1 (platelet endothelial cell adhesion molecule-1), thereby reducing platelet activation. PECAM-1 is also a key participant of the adhesion cascade in the inflammatory process. (415)
Aspirin is widely prescribed to prevent heart attacks because of its ability to inhibit platelet aggregation. Aspirin works by irreversibly blocking the enzyme cyclooxygenase (COX-1). The problem with aspirin is that our bodies need cyclooxygenase enzymes to function correctly. (387,388)
When COX-1 is blocked, the side effects are ulcers and gastrointestinal bleeding (and kidney damage) because our stomachs need the COX-1 enzyme. (387,388)
Flavay® works differently. Flavay® supports the body's own production of nitric oxide. Nitric oxide is produced by endothelial cells in our vessel walls and causes blood platelets to return to their normal, relaxed and smooth condition. (50,53,264,265,274,292,296,302,397)
Flavay® inhibits platelet aggregation through its action with nitric oxide, which safely modulates the activity of the enzymes thromboxane A2, cyclooxygenase (COX-1 and COX-2), 5-lipoxygenase, and other clotting compounds. Most importantly, this protection comes without an increased risk of prolonged bleeding times, or the side effects common to aspirin. (53,230,264,265,274,292,296,302)
In addition, endothelial nitric oxide acts to increase the production of a chemical messenger called "cyclic-GMP" (guanosine monophosphate), which is needed to keep blood platelets relaxed and not prone to clumping or aggregation. Flavay® stimulates the enzyme nitric oxide synthase to produce nitric oxide in the endothelial cells of artery linings. (10,53,265,302,306)
Flavay® also protects against toxic overproduction of nitric oxide by blocking nitric oxide synthase. Research shows Flavay® works to balance nitric oxide activity, both to stimulate normal synthesis and inhibit over-production of nitric oxide. (10,53,265,302,306)
Modulation of nitric oxide activity in the vessels has many more health benefits. Nitric oxide plays a role in many biochemical functions. Nitric oxide improves memory and attention; increases perfusion of kidneys, lungs, and liver by enhancing blood flow; essential to functioning of the cardiovascular system; and it is responsible for the male erection. (10,232-236,265,292,296)
The following clinical trials show Flavay® decreases the level of thromboxane A2 in smokers to the normal level of nonsmokers. (Thromboxane is an enzyme which activates clotting, constricts blood vessels, reduces blood flow and increases blood pressure.)
Flavay® inhibits platelet aggregation as effectively as aspirin. This study shows Flavay® specifically inhibits thromboxane A2 formation by intact platelets. (50)
A similar study demonstrates how smoking raises thromboxane levels in smokers and Flavay® lowers thromboxane levels to normal, similar to levels of nonsmokers. (397)
A series of experiments on adults who smoked at least 15 cigarettes daily demonstrates Flavay® (100 mg per day) is as effective as aspirin (500 mg per day) in preventing platelet reactivity and aggregation. But aspirin significantly increases bleeding time and Flavay® does not. (264)
Interestingly, the clinical studies show a single dose of 100 mg lasted 12 hours but a single dose of 200 mg protected the blood for longer than 24 hours.
Various in vivo and in vitro studies demonstrate Flavay® reduces LDL oxidation. In vivo studies show Flavay® inhibits cyclooxygenase and lipoxygenase of platelets and macrophages reducing thrombotic (blood clot in blood vessel) predisposition. (174)
This study shows Flavay® inhibits platelet activation induced by epinephrine (adrenaline hormone) in vitro as well as in the inflammatory platelet dependent response in vivo suggesting the potential use of Flavay® as an anti-thrombotic (anti-blood clotting inside blood vessels) and as an anti-inflammatory. (398)
Various studies show Flavay® inhibits platelet aggregation through its action with nitric oxide, which safely modulates the activity of the enzymes thromboxane A2, cyclooxygenase (COX-1 and COX-2), 5-lipoxygenase, and other clotting compounds. Most importantly, this protection comes without an increased risk of prolonged bleeding times, or the side effects common to aspirin. (53,230,265,274,292,296,302)
Experiments show Flavay® stimulates the inhibitory receptor PECAM-1 (platelet endothelial cell adhesion molecule-1), thereby reducing platelet activation. PECAM-1 is a major constituent of the endothelial cell intercellular junction and also a key participant in the adhesion cascade leading to extravasation of leukocytes during the inflammatory process. (415)
A double-blind, randomized, placebo-controlled intervention study with 28 male smokers with 200 mg per day of Flavay®. At baseline, after 4 and 8 weeks researchers measured macro- and microvascular function and a cluster of systemic biomarkers for major pathological processes occurring in the vasculature: disturbances in lipid metabolism and cellular redox balance, and activation of inflammatory cells.
In the Flavay® group, serum total cholesterol and LDL decreased significantly by 5% and 7%, respectively in volunteers with elevated baseline levels. Additionally, after 8 weeks the ratio of glutathione to glutathione disulphide in erythrocytes rose from baseline by 22% the Flavay® group. Researchers observed that Flavay® supplementation exerts anti-inflammatory effects in blood towards ex vivo added bacterial endotoxin and significantly reduces expression of inflammatory genes in leukocytes and noted a "significant improvement of overall vascular health" in the Flavay® group. (454)
Flavay® has been extensively tested in humans and sold world-wide for vascular health for 70 years. The cardio-protective activity of Flavay® has been established by many significant studies, demonstrating several important ways in which Flavay® increases blood flow.
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