Flavay safely reduces platelet aggregation (stickiness and increased clotting tendency) without an increased risk of bleeding.

Improve Blood Platelet Reactivity with Flavay

Improve Blood Platelet Reactivity

Flavay® Improves Blood Platelet Reactivity by Improving Endothelial Nitric Oxide Levels

Studies show Flavay® improves the nitric oxide levels produced in vessels walls and thereby causes the platelets to return back to their normal smooth (unsticky) condition. By the same action, the muscles surrounding blood vessels relax (endothelial vasodilation) and blood flow improves. (50,264,265,292,302,306,397)

Research shows Flavay® is particularly effective against increased platelet aggregation (stickiness and increased clotting tendency) caused by smoking. (53,264,265,292,302,306)

Sticky blood is where platelets "activate" to change shape and release inflammatory mediators which cause the platelets to aggregate (stick and clump) to each other and to vessel walls. Activated blood platelets impair circulation, drive progression of atherosclerosis and can cause thrombosis (blood clots in blood vessels). (386,391,394)
Flavay® helps blood platelets return to their normal, smooth (unsticky) condition by improving nitric oxide levels in endothelial cells inside the vessel walls. By the same action, the muscles surrounding the blood vessels relax so that red and white blood cells may circulate freely. Flavay® thereby improves blood flow. (50,53,264,265,274,292,296,302,397)

Why Do Platelets Activate and Aggregate?

Blood platelets are colorless blood cells. When activated, platelets release protein chemicals which cause the platelets and vessel walls to become sticky and lead to clotting. (386)

A large and growing body of evidence shows that platelet activation is not a result of inflammation but a central part of the inflammatory process itself. Scientists have identified "cross-talk" between platelets, vascular endothelium (cells lining vessel walls) and leucocytes (white blood cells) in response to inflammatory stimuli. (399)

Activated platelets secrete inflammatory mediators which cause aggregation (sticking and clumping). (386,391,394)

Experiments show Flavay® stimulates the inhibitory receptor PECAM-1 (platelet endothelial cell adhesion molecule-1), thereby reducing platelet activation. PECAM-1 is also a key participant of the adhesion cascade in the inflammatory process. (415)

Common Causes of Platelet Activation

  • oxidation
  • injury
  • stress hormones
    ("fight or flight response")
  • tobacco smoke
  • diabetes
  • nutritional deficiencies
  • aging (3,8,386)

Platelet activation is not a result of inflammation but a central part of the inflammatory process itself. (399)

The Dangers of Aspirin

Aspirin is widely prescribed to prevent heart attacks because of its ability to inhibit platelet aggregation. Aspirin works by irreversibly blocking the enzyme cyclooxygenase (COX-1). The problem with aspirin is that our bodies need cyclooxygenase enzymes to function correctly. (387,388)

The problem with aspirin is that it irreversibly blocks the COX-1 enzyme which our bodies need to function correctly. (387,388)

When COX-1 is blocked, the side effects are ulcers and gastrointestinal bleeding (and kidney damage) because our stomachs need the COX-1 enzyme. (387,388)

Flavay® is a better and a safe approach.

Flavay® works differently. Flavay® supports the body's own production of nitric oxide. Nitric oxide is produced by endothelial cells in our vessel walls and causes blood platelets to return to their normal, relaxed and smooth condition. (50,53,264,265,274,292,296,302,397) See: ENDOTHELIAL FUNCTION

Flavay® works differently than aspirin. Flavay® works by supporting the body's production of nitric oxide and antioxidant defense systems. (387,388)

Flavay Methods of Action

Improve Blood Platelet Reactivity by Improving Endothelial Function

Flavay® inhibits platelet aggregation through its action with nitric oxide, which safely modulates the activity of the enzymes thromboxane A2, cyclooxygenase (COX-1 and COX-2), 5-lipoxygenase, and other clotting compounds. Most importantly, this protection comes without an increased risk of prolonged bleeding times, or the side effects common to aspirin. (53,230,264,265,274,292,296,302) See: ANTI-INFLAMMATORY

In addition, endothelial nitric oxide acts to increase the production of a chemical messenger called "cyclic-GMP" (guanosine monophosphate), which is needed to keep blood platelets relaxed and not prone to clumping or aggregation. Flavay® stimulates the enzyme nitric oxide synthase to produce nitric oxide in the endothelial cells of artery linings. (10,53,265,302,306)

Flavay® also protects against toxic overproduction of nitric oxide by blocking nitric oxide synthase. Research shows Flavay® works to balance nitric oxide activity, both to stimulate normal synthesis and inhibit over-production of nitric oxide. (10,53,265,302,306)

Modulation of nitric oxide activity in the vessels has many more health benefits. Nitric oxide plays a role in many biochemical functions. Nitric oxide improves memory and attention; increases perfusion of kidneys, lungs, and liver by enhancing blood flow; essential to functioning of the cardiovascular system; and it is responsible for the male erection. (10,232-236,265,292,296)

Flavay® improves endothelial function and nitric oxide levels which dilates blood vessels and causes blood platelets return to their normal smooth condition. (239,265,286,287,292,296)

The following clinical trials show Flavay® decreases the level of thromboxane A2 in smokers to the normal level of nonsmokers. (Thromboxane is an enzyme which activates clotting, constricts blood vessels, reduces blood flow and increases blood pressure.)

Flavay® inhibits platelet aggregation as effectively as aspirin. This study shows Flavay® specifically inhibits thromboxane A2 formation by intact platelets. (50)

A similar study demonstrates how smoking raises thromboxane levels in smokers and Flavay® lowers thromboxane levels to normal, similar to levels of nonsmokers. (397)

A series of experiments on adults who smoked at least 15 cigarettes daily demonstrates Flavay® (100 mg per day) is as effective as aspirin (500 mg per day) in preventing platelet reactivity and aggregation. But aspirin significantly increases bleeding time and Flavay® does not. (264)

Interestingly, the clinical studies show a single dose of 100 mg lasted 12 hours but a single dose of 200 mg protected the blood for longer than 24 hours.

Various in vivo and in vitro studies demonstrate Flavay® reduces LDL oxidation. In vivo studies show Flavay® inhibits cyclooxygenase and lipoxygenase of platelets and macrophages reducing thrombotic (blood clot in blood vessel) predisposition. (174)

This study shows Flavay® inhibits platelet activation induced by epinephrine (adrenaline hormone) in vitro as well as in the inflammatory platelet dependent response in vivo suggesting the potential use of Flavay® as an anti-thrombotic (anti-blood clotting inside blood vessels) and as an anti-inflammatory. (398)

Various studies show Flavay® inhibits platelet aggregation through its action with nitric oxide, which safely modulates the activity of the enzymes thromboxane A2, cyclooxygenase (COX-1 and COX-2), 5-lipoxygenase, and other clotting compounds. Most importantly, this protection comes without an increased risk of prolonged bleeding times, or the side effects common to aspirin. (53,230,265,274,292,296,302)

There is a large and growing body of evidence that shows platelet activation is not a result of inflammation but a central part of the inflammatory process itself. (399)

Experiments show Flavay® stimulates the inhibitory receptor PECAM-1 (platelet endothelial cell adhesion molecule-1), thereby reducing platelet activation. PECAM-1 is a major constituent of the endothelial cell intercellular junction and also a key participant in the adhesion cascade leading to extravasation of leukocytes during the inflammatory process. (415)

Improve Blood Flow

Flavay® has been extensively tested in humans and sold world-wide for vascular health for 70 years. The cardio-protective activity of Flavay® has been established by many significant studies, demonstrating several important ways in which Flavay® improves blood flow. See: CIRCULATION

All body functions require good blood flow.
Feel and think better with Flavay®.

For a healthy mind and body

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I can’t even tell you how much I appreciated finding your product Flavay and the incredible results and relief I have gotten from taking it... I skeptically ordered two bottles... And low and behold, it works. I read that I could take more than 2 that some people had to take 4 or 5 at a time, so I did, hoping and praying, and my prayers were answered. To say thank-you is an understatement, and I have been able to stop all other pain meds. I honestly was on a one way road to nowhere, now I am free again..a feeling I haven’t had in over 12 years. Thank-you!!!!!!!!!!!!!!! —Ms. Beth B.*

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I am not one to review products, but i can't deny some of the benefits i've experienced using both your biomor curcumin and flavay products. I've been taking both for a few months now, and the two major benefits i've noticed are 1) joint strength and mobility (for workouts) as i am lifting much heavier weights without injury 2) I am a paroxsymal Afib sufferer, and my episodes have gone from 2-3 per week down to zero (most weeks). This can't just be a coincidence. I think there is definitely something in your formulas that stop inflammation and get your body in balance and healing itself. —Mr. B.V.W.*

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* Results vary by person and are not guaranteed. NOTE: We do not compensate for our endorsements and testimonials. We do not consider paid testimonials to be nearly as valuable as comments from customers who were not compensated and yet liked the products so much they gave their testimonials anyway.
†These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.