Have proper research studies proven the safety and effectiveness of Flavay? And other frequently asked questions.

Frequently Asked Questions

Frequently Asked Questions


What is Flavay®?


Flavay - International and U.S. Patents and Clinically Proven

Flavay® is a highly specialized, nutritional complex of singles, pairs and triples of a specific molecule called flavan-3-ol, isolated from natural extracts which has been extensively tested and examined clinically for biological antioxidant protection, collagen strengthening, tissue rebuilding, reducing inflammation, improving circulation and cognitive function, and other health producing outcomes. See: What Can Flavay® Do For Your Body?

Flavay® is manufactured using patented processes.

The science behind Flavay® is very complex. Where its single molecules are highly beneficial, the same molecules would be non-nutritive (and have pro-oxidant activity) if they were isolated from their natural partners. So, organic groups of single and small-clusters of specific molecules are selectively preserved while anti-nutritive large-clusters of molecules are removed. Also, native organic acids are retained to protect the otherwise perishable bioactivity, and for other significant benefits. See: Molecular Composition of Flavay®


How safe is Flavay®?


After more than 70 years of human use, no adverse effects have been observed. Furthermore, intensive biological, toxicological, pharmacological and analytical research was conducted for the purpose of registration as a medicine in France and other countries in Europe. In one study, the equivalent of daily doses of up to 35,000 mg for six months were determined to cause no adverse effects. See: Proven Safety of Flavay®

Rigorous testing and many decades of human use have proven Flavay® is very safe for all ages. (1,90-94)

Licensed, patented and sold in France since 1950, the vascular (veins, arteries, capillaries and lymph) protective activity of Flavay® has been established by many significant studies. (3,38-54)


How does Flavay® affect the kidneys and liver?


Flavay® is shown to protect and benefit the kidneys and liver.

Studies show Flavay® supplementation is beneficial in preventing hepatic (liver) and renal (kidney) toxicity in instances of acetaminophen and other drug poisonings. This protection was attributed to detoxification of cytotoxic free radicals and facilitation of DNA repair. Researchers found Flavay® improved blood urea nitrogen and serum creatinine; histological improvement was also noted. (309-311)

Flavay® protects the small vessels in the liver. A double-blind placebo-controlled trial of persons with hepatic (liver) cirrhosis, found Flavay® (300 mg daily) significantly reduced capillary fragility. (45)


Does Flavay® have any contraindications?


No. Flavay® has no known contraindications (conditions under which it should not be used). Flavay® is completely safe and nontoxic. In fact, clinical trials have been conducted in which pregnant women (troubled by varicose veins and other circulatory problems in the legs) safely used Flavay®. (1-3,90-94)

There are no known interactions between Flavay® and other medications. However, if you are taking anticoagulant drugs, be aware that Flavay® is shown to favorably normalize reactivity ("stickiness") of blood platelets. Notify your physician as dosing adjustments may be advised.


Should I consult with my doctor before taking Flavay®?


Yes, always consult your doctor before starting any course of supplementation or diet change if you are under medical care. If you have or suspect you may have a health problem, you should consult your doctor.


Can the active ingredients in Flavay® be obtained in food?


Not in our modern diet. Industrially-produced food no longer contains the active ingredients in Flavay®. See: Why can't we rely on our diet?


Is Flavay® patented?


Yes, Flavay® is manufactured using patented processes.

  • 1948-1951: French patents described methods to extract the active principles in Flavay® for the protection of the vascular system.
  • 1964-1965: French patents for increasing efficiency of the manufacturing process, and a medicine patent for vascular protection.
  • 1969: U.S. Patent No. 3,436,407 for manufacturing and for vascular protection.
  • 1970: a new French patent for manufacturing in a state of purity that conforms with French pharmacopoeia standards.
  • 1987: U.S. Patent No. 4,698,360 to describe the powerful antioxidant properties known as the "radical scavenger effect."

There are more patents, most are French.

Flavay: International and U.S. Patents and Clinically Proven

Flavay® is patented as a scavenger of the free radicals that play a major role in the degradation of collagen and in the initiation, duration and breakdown of inflammation and in ischemia (reduced blood flow).

"[A] method for preventing and fighting the harmful biological effects of free radicals in the organism of warm blooded animals and more especially human beings, namely cerebral involution, hypoxia following atherosclerosis, cardiac or cerebral infarction, tumour promotion, inflammation, ischemia, alterations of the synovial liquid, collagen degradation, among others."
—U.S. Patent No. 4,698,360 (1987).


Have proper research studies proven the effectiveness of Flavay®


Yes. Flavay® is backed by 70 years of scientific research, patents, clinical studies, and extensive testing for safety.

Registered in France since 1950 for use in over-the-counter medications, Flavay® has therefore been consumed in Europe under medical supervision for decades with no reports of adverse side effects.

Flavay: 70 years of science
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Is Flavay® a bioflavonoid?



Some bioflavonoids are toxic and some are inefficacious. Bioflavonoids have very poor bioavailability or none at all. Flavonoids is a very complex category and nearly 20,000 different flavonoids have been characterized. (2-4,89,178,180)

Bioflavonoids are made of a different species of molecule than Flavay®. Bioflavonoids are made of molecules known as "flavonols" (note the "o"). (2-4,89,178)

Flavay® is comprised of molecules known as flavanols (note the "a") which are part of very specifically defined small organic molecular cluster-complexes. (1-4,89)

Major differences between Flavay® and bioflavonoids:

  1. Flavay® binds to proteins (collagen and elastin)—bioflavonoids do not.
  2. Flavay® is highly bioavailable and bioactive—bioflavonoids have very poor bioavailability or none at all.
  3. Flavay® is proven very safe—many bioflavonoids are unsafe.
Binds to collagen? Biologically Active? Non-Toxic and Safe?


Very Poor or None

Some are Toxic


SMALL cluster




LARGE cluster





What is the difference between polyphenols and OPCs?

"What is the difference between the terms, OPCs and polyphenols? In some cases it appears synonymous and in others there appears to be a distinction. On some labels it will say OPCs, but in the supplement facts, it says grape seed extract (vitis vinifera) 95% polyphenols. I am confused."


It's confusing because these terms are used inaccurately in the marketplace. "95% polyphenols" is a useless expression in a scientific context. However, it does reveal a big problem. In most cases, the terms polyphenols and OPCs (oligomeric proanthocyanidins) are used inaccurately for commercial interests—or by mistake.

If "Polyphenols" appears in the Supplement Facts, you may rightly question the standard. Look for whether it's standardized for single- and small-molecule (oligomeric) proanthocyanidins.

diagram of phenol

What are Polyphenols?

Polyphenols are chemicals (derived from plants or petroleum) with a phenol structure (shape).

Polyphenols is a very broad and extremely complex group of more than 100,000 chemical species. The term is widely used ambiguously and confusingly in connection with dietary nutrients, but generally refers to natural chemicals with phenol structural units—with lack of consideration to solubility (ability to dissolve), precipitation (ability to vaporize), and complexation (bonding) phenomena. (178,188)

Most plant-derived polyphenols are antinutritive— which means they interfere with absorption of nutrients with toxic effects. For example, flavonoids are polyphenols which are related by their pigment (color) and certain flavonoids are known to be carcinogenic/genotoxic and mutagenic and dangerous to your health. (89,189-194)

Most of the 100,000 types of polyphenols are unhealthy for consumption.

  • Most polyphenols are nonnutritive or antinutritive, or toxic. (89,189)

  • Some polyphenols (including some flavonoids) are shown to be carcinogenic/genotoxic and mutagenic. (89,189)

  • Some polyphenols (including large proanthocyanidins) are antinutritive and used in production of eco-friendly plastics, resins and adhesives. (195,196)

Let the buyer be aware! There is no American industry standard for accurately identifying and quantifying products sold as proanthocyanidins in the marketplace.

In most cases, the following terms are used inaccurately and have truly lost all scientific meaning in the marketplace (including product labels, magazine and internet articles, and many popular books).

The following terms are used interchangeably for commercial interests—or by mistake—and their differences have truly lost all scientific meaning in the marketplace:

  • polyphenols
  • flavonoids (bioflavonoids)
  • proanthocyanidins (procyanidins)
  • oligomeric proanthocyanidins (OPCs, PCOs)


Are OPCs the same as grape seed extract or pine bark extract?



But the marketplace wrongly uses the terms interchangeably.

Because of commercial interests—or by mistake—the terms, OPCs and proanthocyanidins, have truly lost all of their scientific meaning in the marketplace. In most cases, suppliers and retailers confuse grape seed extracts as being synonymous with OPCs or proanthocyanidins.

At the University of British Columbia, an academic comparative analysis found commercially-produced OPCs "differed substantially... shown to be only 7.2% similar... raising questions about its quantification in units of [antioxidant] activity" and confirming that standardized quantification of OPCs does not exist in the marketplace. (179)


Is Flavay® the same as grape seed extract or pine bark extract?



"Grape seed extract" and "pine bark extract" are vague, nonspecific terms which really have no scientific value. In fact, crude grape seed extract or pine bark extracts are virtually worthless to the consumer—or may be harmful. Some of these extracts contain nothing more than grape seeds or other plant parts which have been pulverized in a food processor.

"Certain bioflavonoids are mutagenic at high doses."

—Jack Masquelier, et. al, "Flavonoides et pycnogenols," Int. J. Vit. Nutr. Res.; 1979. (89)

Bioflavonoids sold in high doses, including "grape seed extracts" are "likely to make you sick."

—"Beware of plant supplements called flavonoids; they could make you sick, warn UC Berkeley public health experts." Free Radical Bio. & Med.; 2000. (194)

There is no relevant pharmaceutical, nutritional, biochemical or analytical definition of grape seed extract or pine bark extract nor is there a standardized manufacturing method. There are no commonly accepted, clear analytical fingerprints or standards for qualifying grape seed extract or pine bark extract. In fact the term is so broad and so vague that "grape seed extract" and "pine bark extract" can and does mean just about anything.


Is Flavay® the same as OPCs (oligomeric proanthocyanidins) in the marketplace?



Other so-called "OPCs" products contain unidentified and untraceable extracts typically labeled vaguely as "grape seed extract" or "pine bark extract." Even a trained observer is left guessing about the origin of the ingredients, method of production, and in which country and according to what standards it was produced.

Let the buyer be aware! There is no American industry standard for accurately identifying and quantifying products sold as proanthocyanidins in the marketplace.

Other so-called "OPCs" products contain unidentified and untraceable extracts typically labeled vaguely as "grape seed extract" or "pine bark extract."

Even a trained observer is left guessing about the origin of the ingredients, method of production, and in which country and according to what standards it was produced.

Most producers of grape seed extracts and pine bark extracts leave the large proanthocyanidin molecules (tannins) in their products in order to bulk up the weight and then allow the consumer to wrongly believe they are consuming small-molecule oligomeric proanthocyanidins (OPCs).

Consumers should also be aware that some manufacturers of grape seed and pine bark extracts have devised ways to synthetically boost the proanthocyanidin numbers for their extracts. However, there is no scientific research to show whether the human body benefits from a synthetic boost.

More importantly, large-clusters of proanthocyanidins are antinutritive and can be unhealthy for consumption. Large proanthocyanidins cause proteins, carbohydrates and nutrients to become indigestible and can result in toxic effects. (189-194,246)

Only the specific small complexes of flavan-3-ol molecules in Flavay® bind to collagen proteins and make vessels stronger. (1,2,18,19,89)

Large proanthocyanidins, also known as tannins, are antinutritive, unsafe in large doses, used in manufacturing exo-friendly plastics, adhesives and resins, and tanning leather. Small, oligo, proanthocyanidins strengthens collagen, improves circulation, reduces inflammation, terminates free radicals, protects cells from oxidation. Singles, flavan-3-ol complexes, very nutritive but only when retained along with its organic small-molecule partners.

Flavay® is Proven Safe and Therapeutic

Flavay® is manufactured under the control of pharmaceutical inspection by the French Ministry of Health.

Patented Manufacturing Processes

More than 70 years of scientific research, patents and clinical studies, rigorous manufacturing controls and comprehensive identity-testing safeguard the quality and consistency of Flavay®.


Do you have questions?

My joints aren't hurting and my back feels better and I'm even able to work better. I'll tell you, I can feel Flavay! —Ms. C.V.*

I have lupus and taking Flavay enables me to move. I'm not able to do without it. I've been taking it for more than a decade and my skin looks younger, in fact people think I'm my kid's sister. —Ms. L.B.*

After about 6 to 9 weeks it made a profound difference. I’ve lost inches in swelling. I cannot say enough about Flavay! Over the years, I’ve stopped and started again and found for vascular and lymphatic edema, nothing is better than Flavay. —Ms. Marie D.*

I just want to say that I love Flavay. When I stop taking it, the pain comes right back. —Mr. Mark H.*

I feel flexibility, while tying my shoes, wow! The simple things work better. I feel a general sense of wellbeing with Flavay. —Mr. Peter M.*

I love your product called Flavay. I feel it does the job! —Mr. Robert B.*

I've got to have my Flavay. Keeps me going. Keeps me young. 4 Flavay every day. —Mr. C.S.*

I had a terrible accident where I fell 20 feet and injured my back and it was really bad. I went from a wheelchair to a cane and now I'm mowing the lawn. Flavay shrank the protruding disk so I could stand up straight again. I've referred many many people to your products, and it worked for them too. —Mr. Dave T.*

Flavay is a product I cannot stop taking. When I stopped taking it for a couple of weeks, my neuropathy and arthritis pain come raging back. So I started again on Flavay and the pain is almost completely gone. —Ms. Elsa D.*

I started taking Flavay for arthritis pain and I feel so much better! I'm so thrilled! —Ms. Susan S.*

After taking Flavay for just a week, my sister is doing things she couldn’t do before, such as bending over to pick things up off the floor. —Mr. Joe C.*

The puffiness in my legs is so much better. Oh my gosh this Flavay is great! —Ms. Joan G.*

Your Flavay really helps my husband's chronic pain syndrome and we're almost out! Please ship asap! —Ms. S.W.*

I was taking Flavay for pain and mobility. Now I take Flavay as much for the benefits to my skin as for joint pain. —Mr. H.S.*

Oh, I just love Flavay! I feel so much better! —Ms. Y.L.*

I can’t even tell you how much I appreciated finding your product Flavay and the incredible results and relief I have gotten from taking it... I skeptically ordered two bottles... And low and behold, it works. I read that I could take more than 2 that some people had to take 4 or 5 at a time, so I did, hoping and praying, and my prayers were answered. To say thank-you is an understatement, and I have been able to stop all other pain meds. I honestly was on a one way road to nowhere, now I am free again..a feeling I haven’t had in over 12 years. Thank-you!!!!!!!!!!!!!!! —Ms. Beth B.*

I am a nutritionist and I have referred two of my clients to take Flavay. Both of my clients have raved about the product. One of my clients has a problem with circulation and she said Flavay really works for her. —Mr. John H.*

I've got to have my Flavay. Keeps me going. Keeps me young. 4 Flavay every day. —Mr. C.S.*

My neighbor is so pleased with Flavay telling me how much better she feels. She has heart problems and taking 2 Flavay per day she has so much energy again and her color is better too. —Ms. C.V.*

I have tried everything else and your Flavay really helps my eyesight. I was having trouble seeing at night and now I don't have that problem anymore. I love Flavay. I also had a blown knee that they had wanted to do surgery on and now I don't have to. I love the Flavay, I really like it! —Ms. T.K.*

I start feeling pain in my joints after a few days of not taking Flavay. —Mr. Mark H.*

My daughter has rheumatoid arthritis in her knees and years ago Flavay had really helped her, so I want to order some more for her. —Ms. K.M.*

For several years I took Flavay for fibromyalgia and it really worked and I felt so much better. Now I need to start again. —Ms. C.H.*

I love your product called Flavay. I feel it does the job! —Mr. R.H.*

I have had joint pain in my hips for a couple years. I have been taking Flavay for about 30 days and I realized I don't have hip joint pain when laying down or sitting for long periods! I will continue to take it daily. —Ms. M.H.*

Thank you so much. I'm desperate!! 😊 Haven't taken them (Flavay and Flavay Plus) for a few months and can tell the difference! —Ms. S.A.*

Since I started taking Flavay I felt so good and I'm hoping to keep getting better. I started taking Flavay for my knee but since I started taking Flavay I've cut way back on asthma meds. The medication affects my brain badly. I want to control asthma instead of it controlling me. Flavay is a big help, I am so happy! —Ms. J.I.*

I began giving my daughter Flavay Plus for ADD and then I decided to add Flavay for my daughter's allergies. I want to tell you, the Flavay works like a charm for my daughter’s allergies. She is 6 years old, and when we ran out of capsules this week she told me, “You've got to get more Flavay!” —Ms. S.S.*

I just wanted to write and say WOW... I was so skeptical of your product at first and really had a negative attitude when I started taking it. I am a 40 yr old female with anxiety, mild ADHD and a host of arthritis and inflammation issues. It was a struggle for me to get out of bed everyday and focus on what needed to be done. I had no focus, no attention span, no energy, and no desire to do anything. About a week into taking Flavay and Flavay Plus, I started noticing that I could think a little clearer. My rheumatoid arthritis flare-ups weren't so bad, though I still have them. feeling better, and having more energy. I never thought I would feel like my old self again. I don't know exactly how you do it,...but this stuff works! I am telling all of my friends to try it because you've given me my old life back! Thank you! —Ms. L.A.*

I am not one to review products, but i can't deny some of the benefits i've experienced using both your biomor curcumin and flavay products. I've been taking both for a few months now, and the two major benefits i've noticed are 1) joint strength and mobility (for workouts) as i am lifting much heavier weights without injury 2) I am a paroxsymal Afib sufferer, and my episodes have gone from 2-3 per week down to zero (most weeks). This can't just be a coincidence. I think there is definitely something in your formulas that stop inflammation and get your body in balance and healing itself. —Mr. B.V.W.*

I damaged both knees in a motor cycle accident, (mostly pain and swelling ). I don't even think about my knees anymore , its been that long since they have caused me any pain. I have been taking Flavay for 3 Years, I had my right wrist diogonsed with carpal tunnel syndrome, ( hand and arm going to sleep) after having surgery on the left arm years ago, did not have the time for surgery( 3 week recovery) but since Flavay no more pain , the pin and needles are gone so I don't wake up in the middle of the night with my arms and hands bothering me. The amazing thing about this product it can take care of problems you just forgot you had, (or just learned to live with) . Now forget about them because the pain is gone. —Mr. B. Hall*

I really notice a difference when taking Flavay Plus, both in inflammation and in my stress levels. —Ms. W.L.*

I'm real happy about Flavay. It seems to have a positive effect on my lymph system. —Ms. R.M.*

I just love Flavay. If you ever need do a commercial, I’ll be happy to do it! —Ms. Linda M.*