Improve mental performance
Boost learning and memory
Normalize Stress Levels
Increase endurance
Turn back brain-aging
Improve Blood Flow to Brain Neuroprotective of Flavay® Effects Against Cognitive Decline Improves Neurotransmitter Activities Reduces Stress-Induced Hormone Levels
Improve mental performance

Clinical trials show Flavay Plus® improves cognitive performance.

A study of 30 children and adults diagnosed with ADD found Flavay® worked just as well as the commonly prescribed stimulant medications, including Ritalin. The subjects were given a battery of computerized and behavior tests to judge their attention, concentration, and other important ADD factors. Tests were conducted three times in three ways: off their usual stimulant meds, back on the meds, and then with Flavay® alone. Off their medications, their ADD symptoms deteriorated. On their medications, they were much improved. With Flavay®, their scores and behavior were just as improved as when they took stimulant drugs. Many of the subjects also had other positive effects. (15)

Chart shows taking Flavay Plus results in improvements in short-term memory after two months: Significant improvement in short-term memory in children, ages 4-14

(Above:) A placebo-controlled study of 120 students shows Flavay Plus® for 40 days improves directed memory, associative learning, free memory, recognition and visual memory. (338)

A double-blind, placebo controlled clinical trial on young healthy university students subjected to standard acute stress tests composed of mental arithmetic under time pressure. Stress was monitored by heart rate. Results show taking Flavay Plus® "scored significantly better, were more clear-headed, confident and composed." (125)

A randomized, double-blind, placebo-controlled study on healthy young golfers with handicaps of 15–40. Results show taking Flavay Plus® improved perceived stress levels and performance (significantly improved the number of good ball flights during tee-off which might result in improved golf scores). (215)

Researchers found Flavay® worked as well as commonly prescribed medications, including Ritalin, on children and adults diagnosed with attention disorders. Many of the subjects also had other positive effects. (15)

Flavay® Protects Memory

Research shows taking Flavay® for six (6) weeks results in neuroprotective effects against cognitive decline. In vivo assays identified 13 proteins in the brain that are favorably mediated by Flavay®, "quantitatively in the opposite direction from previous findings for the same proteins in either Alzheimer's disease or ...neurodegeneration." (385)

Flavay® is shown to mediate 13 harmful proteins in brain cells linked to Alzheimer's and dementia. (385)

Boost learning and memory

Flavay Plus® shows significant improvement in focus and short-term memory in clinical trials.

Chart shows taking Flavay Plus results in significant improvements in short-term memory after two months: Significant improvement in short-term memory in children, ages 4-14

(Above:) Results show taking Flavay Plus® "significantly improved ADHD symptoms and short-term auditory memory in children" in a randomized, double-blind, placebo-controlled study performed on 36 children (ages 4 to 14) who had not previously received any drug treatment related to ADHD.

Main outcome measures included: (i) ADHD symptoms based on DSM-IV-TR; (ii) short-term auditory memory and working memory using the Digit Span Test of the Wechsler Intelligence Scale for Children; and (iii) mental performance to visual stimuli (GO/NO GO task). No adverse events and no side effects were found. (217)

Another study of 15 children (ages 6–12) with ADHD shows taking Flavay Plus® daily for 2 months significantly improved ADHD symptoms. Significant improvement was observed both in inattention and in hyperactivity and impulsiveness, and visual perception was also significantly improved. No adverse events and no side effects were found. (218)

Normalize Stress Levels

Flavay Plus® boosts the weak stress response in the elderly person and calms down exaggerated stress in the healthy young person.

Reduce Stress-Induced Hormone Levels

Research shows Flavay Plus® works to keep the brain's processes within normal limits, raising them when they are low and lowering them when they are high. So Flavay Plus® boosts the weak stress response in the elderly person and calms down exaggerated stress in the healthy young person. (106,114,119)

Both physical and mental stressful conditions cause stress hormones to be released into circulation, even in the young and healthy. Flavay Plus® for athletes prior to starting exercise produced an impressive degree of down-regulation of the stress hormones. Flavay Plus® has the capacity to "normalize" the stress-induced activation of the hypothalamic-pituitary-adrenal axis. A double-blind, placebo-controlled study conducted in Italy shows Flavay Plus® can lower stress-induced hormone (cortisol) production by as much as 30 percent. (117)

Chart shows Flavay Plus significantly inhibits ACTH and cortisol (stress-induced and exercise-induced hormones) in response to exercise.

(Above:) A double-blind, placebo-controlled study of healthy males (ages 24-42) shows Flavay Plus® significantly suppresses cortisol levels in response to exercise. (134)

Several double-blind, placebo-controlled clinical trials show how Flavay Plus® can prevent and improve exercise-induced cortisol levels and other markers related to hard training. Athlete's perception of well-being results in a profound influence in competitive spirit and performance. The research shows taking Flavay Plus® causes measurably better perception of well-being, particularly after the first week of training. Following intense weight-training, cortisol levels were noticeably lower. (121,144,145)

Flavay Plus® helps calm down exaggerated stress and is shown to significantly suppress stress hormone levels in response to exercise. (Mental and physical stress result in the same physiological responses.) (106,114,117,119,134,216)

A double-blind, placebo-controlled study with healthy male volunteers (ages 24-42), performed three sessions of bicycle ergometer tests at one-week intervals. As expected, the physical exercise resulted in a significant increase in ACTH and cortisol levels in the placebo group. However, the Flavay Plus® group found significant suppression in ACTH and cortisol response to exercise. (134)

Another double-blind, placebo-controlled, crossover study was conducted on healthy male athletes. Blood samples were taken at (1) rest, (2) after a 15-minute moderately intense exercise on a cycle ergometer, and (3) during a 65-minute passive recovery period. After ten sessions in ten days, results showed that cortisol levels were significantly reduced in the Flavay Plus® group, testosterone was significantly increased and the ratio between the two hormones was significantly elevated in the Flavay Plus® group—indicating a reduction in stress and improved recovery. (216)

Flavay Plus® boosts the weak stress response in the elderly person and calms down exaggerated stress in the healthy young person. (106,114,119)

Over-training is a natural hazard of competitive sports. During the early stages, your muscles ache, your heart rate and cortisol levels increase, and testosterone levels fall especially in male athletes. Your body can recover after a few days of rest but chronic over-training often causes an unhealthy ratio of the anabolic (muscle-building) hormone testosterone to the catabolic (muscle-wasting) hormone cortisol.

Flavay Plus® is shown to be an effective non-drug and safe alternative for lowering cortisol levels for athletes. (134)

Increase endurance

Flavay Plus® increases endurance and time to exhaustion in clinical trials.

Chart shows Flavay Plus significantly increases endurance. Graph compares placebo baseline, placebo endpoint, Flavay Plus baseline, Flavay Plus endpoint and shows 30% more time to exhaustion with Flavay Plus.

(Above:) After ten days, the group taking Flavay Plus® experienced about 30% more time before exhaustion, while the placebo group experienced no change in a double-blind, placebo controlled study with 14 healthy and trained male athletes who underwent cycling exercise prior to and following the supplementation period. Endurance was measured using a cycle ergometer at 85% VO2 max. (258)

Turn back brain-aging

Clinical trial shows taking Flavay Plus® (4 per day) for 12 weeks resulted in reversal of brain-aging by nearly 14 years.

Chart shows taking 4 Flavay Plus per day for 12 weeks results in reversal of brain-aging by nearly 14 years. Chart shows the following test results: 13.9 years of improvement for remembering names after introduction; 11.6 years of improvement for learning and remembering written information; 7.4 years of improvement for recognizing a previously seen person; and 3.9 years of improvement in dialing a ten-digit phone number from memory. Chart shows taking 4 Flavay Plus per day for 0, 6 and 12 weeks results in significant improvements in elderly subjects in the following tests: memory recognition, memory recall, executive functions, and mental flexibility.

(Above:) Improvements were found in learning and remembering written information, remembering names and recognizing people, and memory of numbers in data from objective neuro-psychological testing shows taking Flavay Plus® (4 per day) for 12 weeks resulted in reversal of brain-aging of nearly 14 years. (126,168)

A study of 75 seniors with age-related memory impairment found taking (4) Flavay Plus® per day for 12 weeks led to improved performance tests related to learning and memory tasks of daily life. (166)

A study of 33 persons with dementia shows equally promising results. This eight-week study shows (4) Flavay Plus® per day can significantly improve dementia. (123)

Studies confirm what many users of Flavay Plus® experience—improved concentration, mental focus and endurance.

Double-Blind, Placebo-Controlled, Crossover Studies = Flavay Plus® (4 per day)

Methods Population Duration Conclusions
Crichton and Peri geriatric rating scales 35 hospitalized senile demented patients, ages 65-91 6 weeks randomized, placebo-controlled, double-blinded and three weeks follow-up Statistically significant behavioral improvement in both scales (219)
Plutchik Geriatric Rating Scale 87 subjects with moderate cognitive deterioration, ages 55-80 8 weeks randomized, placebo-controlled, double-blinded and four weeks follow-up Beneficial for cognitive effects (220)
Brain physiology (EEG) 39 elderly subjects with arteriosclerotic encephalopathy, ages 55+ 12 weeks placebo-controlled, double-blinded and four weeks follow-up Improved discrimination (221)
The Set Test (Isaacs & Akhtar) and parameters like daily living, information, personal memory, non-personal memory 142 subjects with Alzheimer's disease, ages 40-80 12 weeks placebo-controlled, double-blinded with 12- and 24-weeks follow-up Significant improvement (p<0.05) (222)
Learning and memory tasks 51 subjects with Alzheimer's disease, ages 55-80 12 weeks placebo-controlled, double-blinded Improvement in cognitive impairment (223)
Plutchik Geriatric Rating Scale and Buschke Selective Reminding Test 425 geriatric patients with moderate to severe cognitive decline, ages 65-93 24 weeks placebo-controlled, double-blinded Statistically significant improvements (114)

Flavay Methods of Action

Improve Blood Flow to Brain Neuroprotective Effects of Flavay® Against Cognitive Decline Improves Neurotransmitter Activities Reduces Stress-Induced Hormone Levels

Decreased blood flow to the brain plays a major role in dementia and other brain disorders. The result is that the brain becomes starved for oxygen and fuel, producing a low-grade "suffocation." (455) Neurons become more active when blood flow increases. (14,231,339,455)

Clinical trials show Flavay® improves blood flow and strengthens and tones veins, arteries, capillaries, lymph vessels, lymph nodes, and lymphoid tissues. (44-48,59,82,205,249,250)

Flavay - International and U.S. Patents and Clinically Proven

Flavay® is patented as a scavenger of the free radicals that play a major role in the degradation of collagen and in the initiation, duration and breakdown of inflammation and in ischemia (reduced blood flow).
—U.S. Patent No. 4,698,360 (1987).

Flavay® readily crosses the blood-brain barrier, strengthens collagen in the brain's vascular walls and capillaries, and increases circulation and nutrient delivery. Flavay® actually strengthens collagen in vascular walls and capillaries (the smallest vessels), making the vessels stronger and more elastic. (10,38-54,103,402)

Licensed and sold for vascular health in France for more than 65 years, the vascular protective activity of Flavay® has been established by many significant studies. Clinical trials show Flavay® improves blood flow and strengthens and tones veins, arteries, capillaries, lymph vessels, lymph nodes, and lymphoid tissues. (44-48,59,82,205,249,250)

Flavay's® support of healthy blood flow to the brain is important to brain function because studies show that decreased blood flow to the brain plays a major role in dementia and other brain disorders. Also, Flavay® as much as doubles plasma levels of endogenous antioxidants catalase, superoxide dismutase and glutathione, which are essential to cognitive function. Studies confirm what many users of Flavay® experience—striking benefits in improved concentration and mental focus—the classic symptoms of attention deficit disorder. (33,64,64,71,159,231,361,371)

Flavay protects the brain in multiple ways.

(Above:) Flavay® protects cognitive function in multiple ways. In aging and neurodegenerative dysfunctions, neuronal death is triggered by neurotoxicity and/or neuroinflammation. Initiating factors include oxidative stress, DNA damage, protein aggregation and apoptotic (cell-death) cascades. Flavay® has demonstrated to protect the brain against cellular alteration through modulation of neuronal function against neurotoxicity and inhibition of glial-induced inflammation by: CysDA, 5-S-cysteinyldopamine; DHBT1, dihydrobenzothiazine 1; TNF-α, tumor necrosis factor-alpha; IL-1ß, interleukine-1 beta; CRP, C-reactive protein; NO, nitric oxide.

Flavay® Protects Against Neuronal Dysfunction, Neurotoxicity and Neuroinflammation

Oxidative stress-mediated inflammation is attributed to cognitive impairment and neurodegenerative diseases including Alzheimer's disease and Parkinson's disease. Brain aging is also associated with elevated levels of neuro-inflammation which is intimately linked to oxidation. (379-384)

Study shows Flavay® modulates the immune response toward an antiinflammatory pathway which suggests a valid therapeutic measure in mitigating neuro-inflammation in Alzheimer's disease and Parkinson's disease. (407)

Study shows taking Flavay® for six (6) weeks results in neuroprotective effects in the brain against Alzheimer's disease or other neurodegenerative diseases. In vivo assays identified 13 proteins in the brain that are favorably mediated by Flavay®, "quantitatively in the opposite direction from previous findings for the same proteins in either Alzheimer's disease or ...neurodegeneration." (385)

In this study, using both in vitro and in vivo assays, researchers demonstrate Flavay® can "significantly inhibit amyloid β-protein aggregation" and thereby "significantly attenuate Alzheimer's disease-type cognitive deterioration". (403)

Two separate in vivo studies show Flavay® reduces the β-amyloid (Aβ), considered to be responsible for senile plaque formation and which later accumulate in brains of persons with Alzheimer's disease. (404,405)

An in vivo study finds Aβ fibril formation, amyloid plaques and microgliosis in the Alzheimer's diseased brain are reduced by Flavay®. (405,406)

Study shows Flavay® successfully inhibits the accumulation of age-related oxidative DNA damage in areas of the spinal cord and brain. (413)

Study shows Flavay® crosses the blood-brain barrier and is bioavailable in the brain. (402)

Study shows Flavay® provided significant protection against lipid peroxidation and DNA fragmentation in brain tissues in vivo. (272)

Administration of Flavay® helped prevent capillary leaking in the brain, increasing the resistance of tight junctions in the arteriolar capillaries. (102)

Study shows Flavay® inhibiting tau peptide aggregations, as well as dissociating preformed tau peptide aggregates. Results from this study suggest Flavay® may fight tau-associated neurodegenerative disorders by modulating tau-mediated neuropathologic mechanisms. (408)

Oral administration of Flavay® is shown to significantly reduce development of Alzheimer's disease type tau neuropathology in the Alzheimer's diseased brain. Tau is abnormally hyperphosphorylated in Alzheimer's disease and aberrant tau phosphorylation contributes to the neuropathology of Alzheimer's disease and other tauopathies. Anti-aggregation and anti-phosphorylation are main approaches for tau-based therapy. In this study, Flavay® could potently interfere with the assembly of tau peptides into neurotoxic aggregates through mechanisms associated with reduction of extracellular signal-receptor kinase 1/2 signaling in the brain. (409)

Oral administration of Flavay® is shown to significantly reduce decay of motor skills and extend life span in the model of Huntington's disease, a progressive neurodegenerative disorder associated with selective neuronal cell death. Abnormal aggregation of huntingtin protein with polyQ expansion has been shown to be linked to Huntington's disease. Flavay® has previously been shown to interfere with aggregations of proteins involved in neurological disorders, such as amyloid beta peptides (Aβ) and tau protein. This in vivo study shows Flavay® significantly inhibits polyQ aggregation in phaeochromocytoma (PC)-12 cell line containing an ecdysone-inducible protein comprising the first 17 amino acid of huntingtin plus 103 glutamines fused with enhanced GFP. (410)

Flavay® is shown to suppress development of peripheral and central sensitization in temporomandibular joint disorder through repressing phosphorylated-p38, OX-42, and glial fibrillary acidic protein and basal expression of the neuropeptide calcitonin gene-related peptide. (411)

Flavay® improves nitric oxide levels which improves concentration, learning and memory. (14,53,103,202-204,265,274)

Flavay® Improves Nitric Oxide Levels

All higher brain functions require a well-balanced release of nitric oxide in the brain. Nitric oxide acts as neurotransmitters to control communication among brain cells and is deeply involved in concentration, learning and memory. But if not tightly controlled, too much nitric oxide damages brain cells. Excessive production of nitric oxide can cause some of the brain's worst free radical damage and development of neurological diseases. (10,14,202-204,352,353,377,379-384)

Nitric oxide is now recognized as a very important signaling molecules for intercellular and intracellular communication throughout the body. (14,102,232-236,248,352,353,377)

Flavay® protects the blood-brain barrier by improving nitric oxide levels in the microvascular endothelial cells of the blood-brain barrier. (202-204,292,296,374)

Flavay® lowers stress hormones, lowers oxidative stress and protects neurotransmitters by improving nitric oxide levels. (14,53,103,202-204,265,274)

Flavay® also protects against toxic overproduction of nitric oxide by blocking nitric oxide synthase. Research shows Flavay® works to balance nitric oxide activity, both to stimulate normal synthesis and inhibit over-production of nitric oxide. (10,53,265,302,306)

This is important because when nitric oxide is over-produced, a chain reaction begins which causes neurons to break down and destroy surrounding healthy cells. In Alzheimer's, free radicals attack cell membranes of the hippocampus, the memory region. In Parkinson's disease, the area of the brain to suffer the most damage is the "substantia nigra," which produces dopamine, the neurotransmitter responsible for muscle movement and coordination. (14,232-236,240-242)

By improving nitric oxide levels in brain cells, Flavay® supports regulation of the enzymes which control dopamine and norepinephrine, chemicals that carry messages among brain cells and are essential to memory, attention and problem-solving. (14,103,53,202-204,265,274)

Chart of young versus old shows supplementation with Flavay Plus restores healthy youthful levels of dopamine. Dopamine is a brain transmitter which regulates the sense of well-being, reward-behavior, mood and bodily coordination.

(Above:) Flavay Plus® is shown to restore supply and output of dopamine— essential to memory, attention and problem-solving. Dopamine is also associated to the sense of well-being, reward-behavior, mood and bodily coordination. (128-133,331,332)

Chart of young versus old shows supplementation with Flavay Plus restores a healthy supply of acetylcholine. Acetylcholine is a brain transmitter essential to memory, cognition, sleep and neuromuscular control.

(Above:) Flavay Plus® is shown to restore acetylcholine synthesis and release. Acetylcholine is a neurotransmitter essential to memory, cognition, sleep and neuromuscular control. (127)

Change the way you grow older by protecting your memory for the many years ahead.

For a healthy mind and body

Taking Flavay Plus and I feel strong. —Mr. W.P.*

My husband swears by Flavay Plus. He's a truck driver and Flavay Plus keeps him calm and at the same time his energy lasts long. He wouldn't do without it. —Ms. C.K.*

Flavay plus is still the only product that works to combat my ADHD without prescription medication. I am so thankful! —Ms. D.G.*

In 2006 I stopped taking Zoloft because it made me sick. That's when I found Flavay and Flavay Plus and I've been taking it ever since (12 years) and it gets me going every day. Such a difference in my life. It's been very good for me. My wife takes it too. —Mr. P.Z.*

I know taking vitamins is good for you but this is much more than that. Because of taking Flavay and Flavay Plus I experience substantial improvement in mental sharpness, acuity and in the ability to react quickly and stay on top of situations while auto racing. —dentist*

I just wanted to write and say WOW... I was so skeptical of your product at first and really had a negative attitude when I started taking it. I am a 40 yr old female with anxiety, mild ADHD and a host of arthritis and inflammation issues. It was a struggle for me to get out of bed everyday and focus on what needed to be done. I had no focus, no attention span, no energy, and no desire to do anything. About a week into taking Flavay and Flavay Plus, I started noticing that I could think a little clearer. My rheumatoid arthritis flare-ups weren't so bad, though I still have them. feeling better, and having more energy. I never thought I would feel like my old self again. I don't know exactly how you do it,...but this stuff works! I am telling all of my friends to try it because you've given me my old life back! Thank you! —Ms. L.A.*

I have used Flavay and Flavay Plus for almost a month and I really have not felt this healthy for so long. Fantastic energy and better overall. I have ms (small letters intentional, I hate it) and am feeling better even at work, people have commented my skin is better than it has ever been. I have great energy, it is incredible. —Mr. G.S.*

After one month of taking Flavay and Flavay Plus, I feel really good. I feel younger, like I used to feel 5 years ago, so that I want to start a business, and other things like that. My wife says I even look different. —Mr. R.K.*

I take 4 capsules of Flavay Plus every morning and I can keep going all day, and I stay focused too. —Mr. T.C.*

I want to thank you for Flavay Plus, it's just wonderful. My anxiety, panic and stress levels plummeted and my skin became clear and radiant. —Ms. J.C.*

I began giving my daughter Flavay Plus for ADD and then I decided to add Flavay for my daughter's allergies. I want to tell you, the Flavay works like a charm for my daughter’s allergies. She is 6 years old, and when we ran out of capsules this week she told me, “You've got to get more Flavay!” —Ms. S.S.*

My son was born with a cleft palate and learning disabilities. I am no believer in nutrients but Flavay Plus is helping my son to calm down and stay on task. I recently ran out and my son told me that ‘not taking Flavay Plus makes me act crazy,’ so I know he can tell the difference. —Ms. E.W.*

I'm 26 and have a severe case of ADHD, and just recently started taking Flavay Plus. From the first week I was taking three to four pills per day, and feeling the results quite rapidly... I'm thrilled with the results I'm getting with Flavay Plus. —Ms. T.A.*

Flavay Plus has worked amazingly for my son in school. I don't have the same issue with ADHD like he does but I started taking it just because I saw what it did for him and it's helped so much with making me sharper and more clear minded. —Ms. A.M.*

I have had my son on Flavay Plus now for a couple months and his test scores have dramatically improved in school!!! —Ms. M.H.*

It's (Flavay) working! My grandson is doing so much better in school. No more bad text messages from his teacher. I am so grateful. I'm so happy. —Ms. M.P.*

After two weeks my mom (85, with dementia) is telling me she feels good because she is remembering better. I’m very upbeat over this. Flavay Plus is doing just what you thought it would for my mom. —Ms. X.M.*

I ordered Flavay Plus for my son because he just started a job. He said it helps his concentration and really missed your product. —Mr. F.C.*

My sister has been using Flavay Plus and she tried to get me to order it but I resisted. Now my sister is doing better about remembering and focusing while I'm still suffering, so I’ve got to get some for myself. —Ms. Mary C.*

Flavay is terrific. I've had concentration problems, well, for 60 years, all my life. I couldn't have direct eye contact with people when talking with them because I couldn't concentrate. I told jokes but couldn't make people laugh because I couldn't keep my concentration. Now I can look people in the eye. Now I can make people laugh! I don't know how it works but it works and it is terrific. —Mr. Wayne M.*

I've got to have my Flavay. Keeps me going. Keeps me young. 4 Flavay every day. —Mr. C.S.*

My 13-year-old son started taking Flavay for ADD. He came home from school saying, ‘Mom! I felt so smart! I answered all of the questions!’ The teacher backed him up, saying he got every answer correct. So I will keep giving him Flavay. —Ms. Tammy A.*

Flavay works well with my son (6 years-old, with Autism). He's doing work at the proper level, anger issues are gone. —Ms. O.F.*

Thank you so much for all your help. Thank you for also improving my son's lifestyle (taking Flavay). —Ms. R.D.*

My grandson asked to start taking Flavay again. He is 14 years old and has ADD and anxiety and pain going down his arms and so Flavay must have been helping him because he is asking for it. (Follow-up:) Flavay is working! My grandson is doing so much better in school. No more bad text messages from his teacher. I am so grateful. I'm so happy. —Ms. M.P.*

I have found Flavay to be a wonderful product. I buy it for my mum's eyes, but we also notice it improves her cognitive function. —Ms. N.S.*

Your Flavay Plus is wonderful! I'm a nurse and I don't dare tell the doctors what my son is taking, you know they don't like supplements. This product is amazing. I put it in my son's food, he doesn't even know he is taking it. Thanks again for a wonderful product. —Ms. R. Lee*

* Results vary by person and are not guaranteed. NOTE: We do not compensate for our endorsements and testimonials. We do not consider paid testimonials to be nearly as valuable as comments from customers who were not compensated and yet liked the products so much they gave their testimonials anyway.
†These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.