Flavay safely reduces inflammation and allergic activity of histamine.

Control Histamine with Flavay

Safely Reduce Inflammation and Allergies

Flavay® Lowers the Inflammatory and Allergic Activity (Release) of Histamine

Numerous studies demonstrate the anti-inflammatory and anti-allergy activity of Flavay® as it inhibits release (activation) of histamine from mast cells. (3,35,56,78,146,423,425-427)

Allergies are hypersensitive reactions to harmless substances which the body perceives as harmful. When a hypersensitive person is exposed to an allergen, their body releases (activates) histamine to fight the allergen. The release of histamine triggers the typical allergic reactions of inflammation, itching, runny nose, and sneezing. Flavay® reduces release of histamine so symptoms are improved.

Activated histamine causes swelling and inflammation; adrenaline release, vessels and capillaries increase in permeability; dilation of blood vessels; stimulation of gastric acid secretion; broncho-constriction; blood clotting.

Activation and release of histamine accelerates blood flow, dilates capillaries and increases their permeability, which then leaks plasma into surrounding tissue and results in swelling and inflammation.

Cycle of histamine activation pathway. Cycle shows: 1 Free radical activator. 2 inactive hyaluronidase, 3 activated hyaluronidase, 4 inactive histamine, 5 activated histamine 6 which results in inflammation and or allergic reaction.

Cyclical pathway of histamine activation:

  1. Free radical activator,
  2. Inactive hyaluronidase,
  3. Activated hyaluronidase,
  4. Inactive histamine,
  5. Activated histamine,
  6. which results in inflammation and/or allergic reaction.

As the above diagram illustrates, the problem isn't histamine itself but when free radicals interfere with enzymes (and proteins and DNA) inside healthy cells. The result is oxidative damage and inflammation which is linked to degenerative conditions including arthritis, cardiovascular disease, neuro-degenerative disorders, and other chronic conditions. (7,14,346-351,355,356)

Flavay® Protects Histamine from Release

Flavay® is a strong antioxidant which inhibits the release of histamine—a key factor in the promotion of inflammation. Rather than act against histamine, Flavay® protects histamine from the enzyme histidine decarboxylase (step #3, above). Studies show that Flavay® may lower the release of histamine with as much as 86% inhibition of histidine decarboxylase. (3,35,56,78,146)

Anti-inflammatory activity of Flavay: Flavay protects against unfavorable free-radical release of histamine. Cycle shows: 1 Free radical activator. 2 Flavay protects inactive hyaluronidase. 3 results in reduction of hyaluronidase activation. 4 which protects inactive histamine. 5 which reduces histamine activation. 6. which reduces inflammation and allergic response.

Flavay® lowers the inflammatory and allergic activity of histamine by protecting hyaluronidase against activation. (Hyaluronidase activation also breaks down hyaluronic acid and collagen in connective tissue.) (3,35,56,78,146)

Flavay® lowers inflammatory and allergic activity of histamine with as much as 86% inhibition of histidine decarboxylase. (3,35,56,78,146)

Hyaluronidase activation not only causes inflammation, it also breaks down hyaluronic acid and collagen in connective tissue, vessel walls and retinal tissue. Research demonstrates Flavay® reduces the damaging effects of hyaluronidase and protects hyaluronic acid and collagen in connective tissue and vessel walls. See: Flavay® Strengthens Collagen

The Dangers of Antihistamines

Long-term use of antihistamines is linked to dementia.

According to a recent study published in the Journal of American Medicine (JAMA), anticholinergics (antihistamines) have been linked to memory loss and severe cognitive decline. (199)

Histamine is essential for memory and other cognitive functions.

Histamine acts as a neurotransmitter (histaminergic neurotransmission) and immuno-transmitter (histaminergic immunotransmission) when functioning correctly. In fact, histamine is now recognized as a very important signaling molecule for intercellular and intracellular communication throughout the body. (352,353,377)

Histamine is stored in high concentrations in neurons of the hypothalamus, the area of the brain responsible for alertness and attention. A recent study discovered that 70% of their outpatient schizophrenics had abnormal histamine levels. About 50% were low in blood histamine (histapenic) and 20% were high in blood histamine (histadelic). They also found both groups low in serum zinc, which is needed by mast cells and hippocampus terminal vesicles to store histamine. (430)

Flavay® protects histaminergic neurotransmission.

Unlike antihistamines, Flavay® protects histamine in mast cells and hippocampus terminal vesicles and protects memory by mediating harmful proteins in brain cells linked to Alzheimer's and dementia. See: Flavay® Protects Memory

Flavay® is a Safe Alternative to Antihistamines

Flavay® mediates histamine levels without side effects.

Flavay® works differently than antihistamines. Antihistamines interfere with histamine after its release. Flavay®, on the other hand, works before histamine is released. (Flavay® is shown to increase the uptake and re-uptake of histamine into immune cells known as mast cells.) So with Flavay®, histamine is not released, but remains intact (safely stored and not impaired) in mast cells and hippocampus terminal vesicles. This is good because our brains need histamine as a neurotransmitter—histamine is essential for memory and other brain functions. So, Flavay® is effective for allergies without side effects of mental-fog, drowsiness or dry mucous membranes. (3,35,56,78,146,423,425-427)

Numerous studies demonstrate Flavay® inhibits release of histamine from mast cells. Studies demonstrated Flavay® protects the inert hyaluronidase from activation. (Hyaluronidase activation also breaks down the hyaluronic acid in connective tissue, vessels walls and retinal tissue.) This research shows Flavay® has both anti-inflammatory and anti-allergic activity. (35,56,78,146,423,425-427)

Flavay® prevented formation of gastric lesions by 80% in a series of seven in vivo studies conducted over a period of six months. Researchers found Flavay® directly restrained production of histamine from histadine and indirectly restrained release of histamine from mast cells. (146)

In a similar gastric study, Flavay® lowered the production of histamine with as much as 86% by inhibition of the enzyme of histidine decarboxylase. (78)

The anti-inflammatory activity of Flavay® was found twice as strong as phenylbutazone (an NSAID). (56)

Flavay® Reduces Inflammation in Multiple Ways

Flavay® works in multiple ways to lower inflammation: (1) by inhibiting release of compounds that promote inflammation, including histamine, serine proteases, prostaglandins and leukotrienes and (2) by improving vascular strength.

Study shows Flavay® significantly inhibits formation of pro-inflammatory cytokines, interleukin 1-beta, tumor necrosis factoralpha (TNF-alpha). (280)

Taking Flavay is shown to decrease levels of proinflammatory molecules C-reactive protein (CRP), interleukin-6 and tumor necrosis factoralpha (TNF-alpha). (435)

The anti-inflammatory effects of Flavay® are associated to inhibition of peroxide generation by macrophages. (272,278,279)

Several studies show Flavay® inhibits pro-inflammatory mediators phospholipase A2, cyclooxygenase (COX-1 and COX-2), and lipoxygenase thereby reducing destructive ratios and concentrations of prostanoids, leukotrienes and thromboxanes. (Most importantly, this protection comes without the side effects common to NSAIDs.)(53,265,274,292,296,302)

Flavay® is shown to inhibit lipoxygenase (LOX) and cyclooxygenase (COX). (185,230)

Flavay® enhanced IL-2 production by mitogen-stimulated splenocytes, decreased production of interleukin 6, and increased the cytotoxicity of natural killer cells. (318)

Two months of Flavay® significantly improved T- and B-cell function. (308)

Study shows Flavay® decreases levels of proinflammatory molecules C-reactive protein (CRP), interleukin-6 and tumor necrosis factoralpha (TNF-alpha). (435)

Flavay® significantly suppressed gastric mucosal injury, in a dose-dependent manner in vivo. Myeloperoxidase (MPO) activities (marker of inflammation) were also significantly inhibited. Endogenous antioxidant, superoxide dismutase (SOD) activities were significantly stimulated. As to gastrointestinal hormones, the secretion of gastrin, somatostatin, and histamine were significantly inhibited, while prostaglandin E2 secretion was significantly stimulated. (425)

Flavay - International and U.S. Patents and Clinically Proven

Flavay® is patented as a scavenger of the free radicals that play a major role in the degradation of collagen and in the initiation, duration and breakdown of inflammation and in ischemia (reduced blood flow).

"[A] method for preventing and fighting the harmful biological effects of free radicals in the organism of warm blooded animals and more especially human beings, namely cerebral involution, hypoxia following atherosclerosis, cardiac or cerebral infarction, tumour promotion, inflammation, ischemia, alterations of the synovial liquid, collagen degradation, among others."
—U.S. Patent No. 4,698,360 (1987).

Flavay® reduces inflammation and allergies by preventing release of compounds that promote inflammation, including histamine, serine proteases, prostaglandins and leukotrienes. (18,25,61,74,81)

Since I started taking Flavay I felt so good and I'm hoping to keep getting better. I started taking Flavay for my knee but since I started taking Flavay I've cut way back on asthma meds. The medication affects my brain badly. I want to control asthma instead of it controlling me. Flavay is a big help, I am so happy! —Ms. J.I.*

I began giving my daughter Flavay Plus for ADD and then I decided to add Flavay for my daughter's allergies. I want to tell you, the Flavay works like a charm for my daughter’s allergies. She is 6 years old, and when we ran out of capsules this week she told me, “You've got to get more Flavay!” —Ms. S.S.*

I have a friend who takes Flavay and he takes 4 capsules a day. It controls his asthma. Sounds great to me so I’ll give it a try. —Mr. J.G.*

My mother is doing really well. Her eyes aren't dry, her mouth isn't dry, her asthma is much better and she has more energy. She was already taking medications for these things, without such progress, and now she's doing much better since she started taking Flavay several months ago. —Ms. X. Yang*

Sinus doctors, infectious disease specialists and others have been called in, all to no avail. I discovered Flavay and began its use about five days after the last treatment with antibiotics in February. I have been on Flavay for about four months now and the bacteria HAVE NOT RETURNED!! What western medical science could not do, Flavay has accomplished. I am free of lung infection for the first time in years! Apparently, the sinuses have been impacted for much longer than that. Thank you Flavay! There have other health improvements as well but the bronchial issue is the life changer. —Mr. Bill F.*

I'm now in my 14th month of no bacteria in my lungs since starting Flavay. Prior to that I had 13 episodes of various bacteria cultures reinvading after an antibiotic had killed off a culture - this over a 25 month period. —Mr. Bill F.*

I have not had a cold/sinus problems for years and years of taking Flavay. I haven't had my regular dose of Flavay for at least two months because I messed up my ordering. Today I have to go to the doctor for a sinus infection. Never again will I go without my Flavay. —Ms. T.M.*

Flavay is just amazing! Thank goodness, it helps my allergies, the difference in how I feel overall, it’s just amazing. And my husband told me, I don’t know what you’re doing, but you look so good! (I’m taking 4 per day, and some days I take more.) —Ms. L.L.*