Boost Nitric Oxide Levels for Better Blood Flow.

Improve Endothelial Function and Control Nitric Oxide Levels with Flavay

Endothelial (vessels), Neurons (brain) and Immune Cells

What Does Nitric Oxide Do?

Nitric oxide acts as a signaling molecule for the whole body.

Nitric oxide is a gas molecule used by every tissue and organ of our body, from our muscles to our eyes to our brain to the disease-fighting cells of our immune system. A large and growing body of research reveals how important nitric oxide is to each of our body systems. An imbalance in nitric oxide affects us in many ways and loss of nitric oxide function is one of the earliest indicators of disease. (203,204,446,459)

Biological Functions of Nitric Oxide

Nitric oxide turns genes on-and-off throughout the body.

Nitric oxide in physiological, biochemical and pathological systems. Cardiovascular system: - Vasodilation - Microvascular tone regulation - Leukocyte adhesion - Platelet aggregation/inhibition - Microvascular permeability. Neurological system: - Learning - Memory - Neural protection - Neuronal toxicity - Neuronal development - Neurotransmission - Nociception. Excretory system: - Glomerular filtration - Renal vasodilation - Renal endothelial function. Vision: ∙ Neurotransmitter within the retina - Regulation of retinal blood flow - Visual transduction - Effector in photoreceptors - Muscle tone in retinal and choroidal circulation.  Endocrine system: - Posterior pituitary hormones gonadotropin hypothalamic releasing factor. Immune system: - Innate immunity - Cytotoxic chemical - Cellular injury protection - Superoxide radical quenching. Respiratory system: - Bronchial dilation - Pulmonary vascular reactivity
  - Alveolar-capillary membrane permeability. Urogeneital system: - Reninsecretion - Penile erection
  - Ferilization - Spermatogenisis, oogenesis, ovulation.

(Above:) Nitric oxide acts as a signaling molecule and loss of nitric oxide function is one of the earliest indicators of disease. (446,459)

Nitric Oxide Toxicity

Loss of nitric oxide function is one of the earliest indicators of disease.

While nitric oxide is essential for life, excessive amounts of nitric oxide can be deadly and actually contribute to heart disease and strokes, arthritis, asthma and Alzheimer's disease. (10,239,265,292,296)

Nitric oxide is essential in fighting infection, killing tumor cells and promoting wound-healing. As long as nitric oxide is produced in the right amount, it's beneficial to the body. But when nitric oxide is produced in excess, it causes some of the body's worst free-radical damage. (14,232-236)

Our immune system uses nitric oxide as a signaling molecule to activate important white blood cells (macrophages) to fight infection, kill tumor cells and promote wound healing. Activation of white blood cells causes endothelial cells to create superoxide rather than nitric oxide. (439)

Studies show Flavay® protects macrophage white blood cells and their disease-fighting activity. (14,103,261,271,301)

When endothelial dysfunctions, the endothelial cells produce superoxide instead of nitric oxide. Blood flow decreases, muscles surrounding vessels constrict, platelets activate (sticky)

Oxidative stress causes endothelial dysfunction, which is when endothelial cells create superoxide (rather than nitric oxide). (439)

The Good, The Bad and The Ugly

Nitric Oxide, Superoxide and Peroxynitrite

Nitric Oxide (Good) is Changed by Superoxide (Bad) into Peroxynitrite (Ugly)

Oxidative stress causes nitric oxide to react with superoxide to form peroxynitrite, which damages endothelial cells. Further, peroxynitrite is metabolized to form the hydroxyl radical and also oxidizes tetrahydropterin, which is a cofactor of endothelial nitric oxide synthase, and as a result, endothelial cells create superoxide—rather than nitric oxide. (439)

Nitric oxide can both promote and inhibit lipid peroxidation.

By itself, nitric oxide acts as a potent inhibitor of the lipid peroxidation chain reaction and potential initiators of lipid peroxidation. However, when in the presence of superoxide, nitric oxide forms peroxynitrite, a powerful oxidant capable of initiating lipid peroxidation and oxidizing lipid soluble antioxidants. (346)

Lipid peroxidation is where fat-heavy membranes (like brain cells) become rancid (peroxidized) and cause a chain reaction, causing neurons to break down and destroy surrounding healthy cells. Lipid peroxidation appears to be the final common pathway for many neurological illnesses—specific symptoms depend on which area of the brain is under attack. In Alzheimer's, cell membranes of the hippocampus (memory region) fall prey to free-radical attack. In Parkinson's, the 'substantia nigra' (which produces dopamine) suffers the most damage. (10,239,265,292,296)

Nitric oxide plays a major role in the function of the blood-brain barrier which consists mainly of endothelial cells. (202-204,374)

Flavay® Improves Nitric Oxide Levels
by Improving Endothelial Dysfunction

Flavay® elevates nitric oxide synthesis to normal levels

Flavay® improves nitric oxide levels by favorably elevating nitric oxide synthesis and antioxidant levels, and thereby improving endothelial dysfunction. Both in vivo and clinical studies show Flavay® balances nitric oxide activity, both to stimulate normal synthesis and inhibit over-production of nitric oxide. Flavay® protects against toxic overproduction of nitric oxide by blocking nitric oxide synthases. (10,53,261,265,302,306,315,372,414)

Flavay® is shown to improve vasodilation and mildly inhibit angiotensin-converting enzyme (ACE) by modulating nitric oxide metabolism in endothelial cells. (292,296,358)

Also, endothelial nitric oxide acts to increase the production of a chemical messenger called "cyclic-GMP" (guanosine monophosphate), which is needed to keep blood platelets relaxed and not prone to clumping or aggregation. (239,265,286,287,292,296)

Flavay® Elevates Antioxidant Levels

Research also shows taking Flavay® specifically increases vitamin E (a-tocopherol) antioxidant levels in endothelial cells. (292)

A study comparing activity and synthesis of superoxide dismutase (SOD) and nitric oxide levels in diabetic and non-diabetic cerebellum and cerebral cortex shows diabetes significantly decreases synthesis and activity of SOD and Flavay® significantly increases synthesis of SOD. Also, diabetes reduces synthesis of nitric oxide but Flavay® elevates nitric oxide levels back to normal. (372)

Taking Flavay® as much as doubles plasma antioxidant levels and activities of vitamins C and E and A, and catalase, superoxide dismutase (SOD) and glutathione (GPx). (33,64,64,71,361,371)

For good cardiovascular and brain health, our body needs to maintain the right balance of nitric oxide—and that's what Flavay® effectively does. (10,239,265,292,296)

Flavay improves endothelial function and nitric oxide levels in endothelial cells and platelets. Blood flow increases, muscles surrounding vessels relax (vessel dilate), platelets relax (unsticky)

Both in vivo and clinical studies demonstrate that taking Flavay® stimulates the enzyme nitric oxide synthase to produce nitric oxide in the endothelial cells of vessel linings. (53,261,265,302,343,344,361,362,419,421,436,437,438)

Studies show Flavay® improves endothelial function so nitric oxide levels are restored, muscles surrounding vessels relax and blood flow increases. (239,265,286,287,292,296)

Endothelial Function = Blood Flow

Flavay® Increases Blood Flow in Clinical Trials

In clinical trials, Flavay® improved circulation, lessened impaired venous backflow, sealed leaky capillaries and prevented outflow of blood or liquid. (44-48,249,250)

Flavay® increase capillary resistance, decreased capillary permeability, and increased rate of lymph flow. (47,48,82,205)

Flavay clinical trial of persons with serious venous problems shows 96% experienced improvement in circulation. 41% very good improvement, 28% good improvement, 27% improvement.

(Above:) 75 out of 78 (96%) subjects with serious circulation problems found very good improvement in taking Flavay®. (44)

Both human and scientific studies show Flavay® induces vasorelaxation and vasodilation by nitric oxide formation in endothelial cells by endothelial nitric oxide synthase (eNOS). (53,265,261,302,314,343,344,361,362,418,419,420)

Studies show Flavay® improves vasodilation and mildly inhibits angiotensin-converting enzyme (ACE) by modulating nitric oxide metabolism in endothelial cells. (292,296)

Studies show Flavay® maintains optimal nitric oxide levels, it both stimulates normal synthesis of nitric oxide and inhibits overproduction of nitric oxide. Flavay® significantly suppresses inducible nitric oxide synthase (iNOS) gene expression and NO production in endothelial cells, thereby directly protecting vascular walls against damage. (53,265,302,343,344,361,362,414)

Study shows Flavay® improves endothelial progenitor cells viability and function, while preventing endothelial dysfunction. (421)

Flavay® possesses endothelium-dependent-relaxing (EDR) activity in blood vessels by increasing nitric oxide production and stimulates vascular endothelial growth factor, a signaling factor involved in initiation of wound healing. (53,265,274)

Flavay® promotes nitric oxide production by vascular endothelium, inhibits the synthesis of thromboxane in platelets and leukotriene in neutrophils, modulates the synthesis and secretion of lipoproteins, arrests tumor growth, and inhibits carcinogenesis in different models. (10,265,302,306)

Nitric oxide stimulates collagen synthesis and subsequent healing at wound sites. (312,313)

In addition, the induction of vascular endothelial growth factor (VEGF) is a crucial step in the reepithelialization phase of skin repair. (314,315)

Flavay® is shown to stimulate the expression of VEGF in cultured keratinocytes, showing Flavay® supports wound healing. (316,317)

Experiments show Flavay® relaxes sympathomimetic-induced contractions in a concentration-dependent manner. Flavay® also increases nitric oxide (NO) levels, counteracting the vasoconstrictor effects of sympathomimetics. (10,265)

In endothelial cells challenged with reactive nitrogen species, Flavay® protected against vitamin E depletion, potentially protecting vascular endothelium from oxidative stress from reactive nitrogen species such as nitric oxide. (261,301)

Study comparing activity and synthesis of superoxide dismutase (Cu/Zu-SOD) and nitric oxide in the diabetic and non-diabetic cerebellum and cerebral cortex shows: Diabetes significantly decreases synthesis and activity of Cu/Zu-SOD and Flavay® significantly increases synthesis of Cu/Zu-SOD. Diabetes reduces synthesis of nitric oxide and Flavay® elevates levels back to normal. (372)

Study shows daily supplementation of Flavay® improves vascular endothelial dysfunction associated to diabetes mellitus. Flavay® is shown to significantly improve vasodilation and to preserve norepinephrine-induced contractions. (424)

Studies show Flavay® improves endothelial dysfunction, nitric oxide synthesis and antioxidant levels. (10,53,261,265,302,306,315,372,414)

Your blood flows better and your joints hurt less with Flavay®.

My joints aren't hurting and my back feels better and I'm even able to work better. I'll tell you, I can feel Flavay! —Ms. C.V.*

I have lupus and taking Flavay enables me to move. I'm not able to do without it. I've been taking it for more than a decade and my skin looks younger, in fact people think I'm my kid's sister. —Ms. L.B.*

After about 6 to 9 weeks it made a profound difference. I’ve lost inches in swelling. I cannot say enough about Flavay! Over the years, I’ve stopped and started again and found for vascular and lymphatic edema, nothing is better than Flavay. —Ms. Marie D.*

I just want to say that I love Flavay. When I stop taking it, the pain comes right back. —Mr. Mark H.*

I feel flexibility, while tying my shoes, wow! The simple things work better. I feel a general sense of wellbeing with Flavay. —Mr. Peter M.*

I love your product called Flavay. I feel it does the job! —Mr. Robert B.*

I've got to have my Flavay. Keeps me going. Keeps me young. 4 Flavay every day. —Mr. C.S.*

I had a terrible accident where I fell 20 feet and injured my back and it was really bad. I went from a wheelchair to a cane and now I'm mowing the lawn. Flavay shrank the protruding disk so I could stand up straight again. I've referred many many people to your products, and it worked for them too. —Mr. Dave T.*

Flavay is a product I cannot stop taking. When I stopped taking it for a couple of weeks, my neuropathy and arthritis pain come raging back. So I started again on Flavay and the pain is almost completely gone. —Ms. Elsa D.*

I started taking Flavay for arthritis pain and I feel so much better! I'm so thrilled! —Ms. Susan S.*

After taking Flavay for just a week, my sister is doing things she couldn’t do before, such as bending over to pick things up off the floor. —Mr. Joe C.*

The puffiness in my legs is so much better. Oh my gosh this Flavay is great! —Ms. Joan G.*

Your Flavay really helps my husband's chronic pain syndrome and we're almost out! Please ship asap! —Ms. S.W.*

I was taking Flavay for pain and mobility. Now I take Flavay as much for the benefits to my skin as for joint pain. —Mr. H.S.*

Oh, I just love Flavay! I feel so much better! —Ms. Y.L.*

I can’t even tell you how much I appreciated finding your product Flavay and the incredible results and relief I have gotten from taking it... I skeptically ordered two bottles... And low and behold, it works. I read that I could take more than 2 that some people had to take 4 or 5 at a time, so I did, hoping and praying, and my prayers were answered. To say thank-you is an understatement, and I have been able to stop all other pain meds. I honestly was on a one way road to nowhere, now I am free again..a feeling I haven’t had in over 12 years. Thank-you!!!!!!!!!!!!!!! —Ms. Beth B.*

I am a nutritionist and I have referred two of my clients to take Flavay. Both of my clients have raved about the product. One of my clients has a problem with circulation and she said Flavay really works for her. —Mr. John H.*

I've got to have my Flavay. Keeps me going. Keeps me young. 4 Flavay every day. —Mr. C.S.*

My neighbor is so pleased with Flavay telling me how much better she feels. She has heart problems and taking 2 Flavay per day she has so much energy again and her color is better too. —Ms. C.V.*

I have tried everything else and your Flavay really helps my eyesight. I was having trouble seeing at night and now I don't have that problem anymore. I love Flavay. I also had a blown knee that they had wanted to do surgery on and now I don't have to. I love the Flavay, I really like it! —Ms. T.K.*

I start feeling pain in my joints after a few days of not taking Flavay. —Mr. Mark H.*

My daughter has rheumatoid arthritis in her knees and years ago Flavay had really helped her, so I want to order some more for her. —Ms. K.M.*

For several years I took Flavay for fibromyalgia and it really worked and I felt so much better. Now I need to start again. —Ms. C.H.*

I love your product called Flavay. I feel it does the job! —Mr. R.H.*

I have had joint pain in my hips for a couple years. I have been taking Flavay for about 30 days and I realized I don't have hip joint pain when laying down or sitting for long periods! I will continue to take it daily. —Ms. M.H.*

Thank you so much. I'm desperate!! 😊 Haven't taken them (Flavay and Flavay Plus) for a few months and can tell the difference! —Ms. S.A.*

Since I started taking Flavay I felt so good and I'm hoping to keep getting better. I started taking Flavay for my knee but since I started taking Flavay I've cut way back on asthma meds. The medication affects my brain badly. I want to control asthma instead of it controlling me. Flavay is a big help, I am so happy! —Ms. J.I.*

I began giving my daughter Flavay Plus for ADD and then I decided to add Flavay for my daughter's allergies. I want to tell you, the Flavay works like a charm for my daughter’s allergies. She is 6 years old, and when we ran out of capsules this week she told me, “You've got to get more Flavay!” —Ms. S.S.*

I just wanted to write and say WOW... I was so skeptical of your product at first and really had a negative attitude when I started taking it. I am a 40 yr old female with anxiety, mild ADHD and a host of arthritis and inflammation issues. It was a struggle for me to get out of bed everyday and focus on what needed to be done. I had no focus, no attention span, no energy, and no desire to do anything. About a week into taking Flavay and Flavay Plus, I started noticing that I could think a little clearer. My rheumatoid arthritis flare-ups weren't so bad, though I still have them. feeling better, and having more energy. I never thought I would feel like my old self again. I don't know exactly how you do it,...but this stuff works! I am telling all of my friends to try it because you've given me my old life back! Thank you! —Ms. L.A.*

I am not one to review products, but i can't deny some of the benefits i've experienced using both your biomor curcumin and flavay products. I've been taking both for a few months now, and the two major benefits i've noticed are 1) joint strength and mobility (for workouts) as i am lifting much heavier weights without injury 2) I am a paroxsymal Afib sufferer, and my episodes have gone from 2-3 per week down to zero (most weeks). This can't just be a coincidence. I think there is definitely something in your formulas that stop inflammation and get your body in balance and healing itself. —Mr. B.V.W.*

I damaged both knees in a motor cycle accident, (mostly pain and swelling ). I don't even think about my knees anymore , its been that long since they have caused me any pain. I have been taking Flavay for 3 Years, I had my right wrist diogonsed with carpal tunnel syndrome, ( hand and arm going to sleep) after having surgery on the left arm years ago, did not have the time for surgery( 3 week recovery) but since Flavay no more pain , the pin and needles are gone so I don't wake up in the middle of the night with my arms and hands bothering me. The amazing thing about this product it can take care of problems you just forgot you had, (or just learned to live with) . Now forget about them because the pain is gone. —Mr. B. Hall*

I really notice a difference when taking Flavay Plus, both in inflammation and in my stress levels. —Ms. W.L.*

I'm real happy about Flavay. It seems to have a positive effect on my lymph system. —Ms. R.M.*

I just love Flavay. If you ever need do a commercial, I’ll be happy to do it! —Ms. Linda M.*